help AutoSavehmmOFFHomeInsertDrawDesignLayoutReferencesMailingsReviewViewAcrobatTell meShareO CommentsHelvetica N... v12A AАa vAaBbCcDcAaBbCcDdE AaBb(AaBbCcDdEeAaBbCcDdEeev AvNo SpacingStylesPaneDictateCreate and ShareAdobe PDFPasteARequestSignaturesIUv ab x,NormalHeading 1Heading 2TitleX Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020.Buy1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability,how much nifedipine is eliminated from this patient's body every 24 hours at steadystate? Please expain2. A female patient (48 years old, 70 kg) with an acute exacerbation of asthma is takento the emergency department in severe distress. The emergency physician decides tobegin aminophylline therapy by administration of a 450 mg IV aminolehuline loadingdose followed by a continuous infusion of aminophylline.Pharmacokinetic data for aminophylline:Volume of distribution= 0.5 L/kg or 35L (for 70kg person)• Target concentration = 10-15 mg/LElimination half-life = 20 hoursBioavailability = 90%Protein Binding = 40%-Explain the purpose for an aminophylline loading dose in this patient before starting acontinuous IV infusion of aminophylline?-If the clinical staff forgets to begin the aminophylline continuous infusion after theaminophylline loading dose, then approximately how many hours will it take for theaminophylline blood concentration to fall below the therapeutic range? Show yourcalculation or explain how you answered this question.-What is the oral maintenance dose required for this patient, dosed twice perday? Show your calculation or explain how you answered this question.3. A patient is taking felodipine once daily. Felodipine is extensively metabolized byCYP3A4. About two weeks ago this patient also started taking carbamazepine orallytwice daily. Carbamazepine is a potent inducer of CYP3A4. What are the changesassociated with felodipine pharmacokinetics that would have occurred over the lasttwo weeks in this patient?-Which of the following best describes the impact of carbamazepine onthe percent of felodipine metabolized-Which of the following best describes the impact of carbamazepine on the volume ofdistribution of felodipine?-Which of the following best describes the impact of carbamazepine on plasmaconcentrations of felodipine-Which of the following best describes the impact of carbamazepine on the half-life offelodipine?-Which of the following best describes the impact of carbamazepine onPage 1 of 2338 wordsEnglish (United States)EO Focus106%lili AutoSavehmmOFFHomeInsertDrawDesignLayoutReferencesMailingsReviewViewAcrobatTell meShareO CommentsHelvetica N... v12A AАa vAaBbCcDcAaBbCcDdE AaBb(AaBbCcDdEeAaBbCcDdEeev AvStylesPaneDictateCreate and ShareAdobe PDFPasteNo SpacingARequestSignaturesIUv ab x,NormalHeading 1Heading 2TitleO Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020.Buy3. A patient is taking felodipine once daily. Felodipine is extensively metabolized byCYP3A4. About two weeks ago this patient also started taking carbamazepine orallytwice daily. Carbamazepine is a potent inducerassociated with felodipine pharmacokinetics that would have occurred over the lasttwo weeks in this patient?CYP3A4. What are the changes-Which of the following best describes the impact of carbamazepine onthe percent of felodipine metabolized-Which of the following best describes the impact of carbamazepine on the volume ofdistribution of felodipine?-Which of the following best describes the impact of carbamazepine on plasmaconcentrations of felodipine-Which of the following best describes the impact of carbamazepine on the half-life offelodipine?-Which of the following best describes the impact of carbamazepine onthe clearance of felodipine?Group of answer choicesNo changeDecreaseIncreasePage 1 of 2338 wordsEnglish (United States)E 3 Focus106%lili

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help AutoSavehmmOFFHomeInsertDrawDesignLayoutReferencesMailingsReviewViewAcrobatTell meShareO CommentsHelvetica N... v12A AАa vAaBbCcDcAaBbCcDdE AaBb(AaBbCcDdEeAaBbCcDdEe>ev AvNo SpacingStylesPaneDictateCreate and ShareAdobe PDFPasteARequestSignaturesIUv ab x,NormalHeading 1Heading 2TitleX Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020.Buy1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability,how much nifedipine is eliminated from this patient's body every 24 hours at steadystate? Please expain2. A female patient (48 years old, 70 kg) with an acute exacerbation of asthma is takento the emergency department in severe distress. The emergency physician decides tobegin aminophylline therapy by administration of a 450 mg IV aminolehuline loadingdose followed by a continuous infusion of aminophylline.Pharmacokinetic data for aminophylline:Volume of distribution= 0.5 L/kg or 35L (for 70kg person)• Target concentration = 10-15 mg/LElimination half-life = 20 hoursBioavailability = 90%Protein Binding = 40%-Explain the purpose for an aminophylline loading dose in this patient before starting acontinuous IV infusion of aminophylline?-If the clinical staff forgets to begin the aminophylline continuous infusion after theaminophylline loading dose, then approximately how many hours will it take for theaminophylline blood concentration to fall below the therapeutic range? Show yourcalculation or explain how you answered this question.-What is the oral maintenance dose required for this patient, dosed twice perday? Show your calculation or explain how you answered this question.3. A patient is taking felodipine once daily. Felodipine is extensively metabolized byCYP3A4. About two weeks ago this patient also started taking carbamazepine orallytwice daily. Carbamazepine is a potent inducer of CYP3A4. What are the changesassociated with felodipine pharmacokinetics that would have occurred over the lasttwo weeks in this patient?-Which of the following best describes the impact of carbamazepine onthe percent of felodipine metabolized-Which of the following best describes the impact of carbamazepine on the volume ofdistribution of felodipine?-Which of the following best describes the impact of carbamazepine on plasmaconcentrations of felodipine-Which of the following best describes the impact of carbamazepine on the half-life offelodipine?-Which of the following best describes the impact of carbamazepine onPage 1 of 2338 wordsEnglish (United States)EO Focus106%lili AutoSavehmmOFFHomeInsertDrawDesignLayoutReferencesMailingsReviewViewAcrobatTell meShareO CommentsHelvetica N... v12A AАa vAaBbCcDcAaBbCcDdE AaBb(AaBbCcDdEeAaBbCcDdEe>ev AvStylesPaneDictateCreate and ShareAdobe PDFPasteNo SpacingARequestSignaturesIUv ab x,NormalHeading 1Heading 2TitleO Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020.Buy3. A patient is taking felodipine once daily. Felodipine is extensively metabolized byCYP3A4. About two weeks ago this patient also started taking carbamazepine orallytwice daily. Carbamazepine is a potent inducerassociated with felodipine pharmacokinetics that would have occurred over the lasttwo weeks in this patient?CYP3A4. What are the changes-Which of the following best describes the impact of carbamazepine onthe percent of felodipine metabolized-Which of the following best describes the impact of carbamazepine on the volume ofdistribution of felodipine?-Which of the following best describes the impact of carbamazepine on plasmaconcentrations of felodipine-Which of the following best describes the impact of carbamazepine on the half-life offelodipine?-Which of the following best describes the impact of carbamazepine onthe clearance of felodipine?Group of answer choicesNo changeDecreaseIncreasePage 1 of 2338 wordsEnglish (United States)E 3 Focus106%lili

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1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability, how much nifedipine is eliminated from this patient's body every 24 hours at steady state? Please expain