11. Explain the role of cytochrome c, Bax/Bac, Fas receptor-ligand, caspases, IGFBP3 in causing apoptosis of cells, based on the figures given below. death ligand cytotoxic cell death receptor plasma membrane granzyme B executioner caspase 3 caspase 8 initiator procaspases caspase 8 caspase 10 tBid executioner procaspases Bid `cytochrome e Apaf-1 apoptosome caspase 9 ICAD lamin death substrates vimentin actin etc. Figure 934 The Biology of Cancer (O Garland Science 2014)

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter6: Cell Communication
Section: Chapter Questions
Problem 4TYU
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11. Explain the role of cytochrome c, Bax/Bac, Fas receptor-ligand, caspases, IGFBP3 in causing
apoptosis of cells, based on the figures given below.
death
ligand
cytotoxic cell
death
receptor
plasma membrane
-granzyme B
executioner
caspase 3
initiator
caspase 8
procaspases
caspase 8
caspase 10
tBid
executioner
Bid
cytochrome c
procaspases
Apaf-1
apoptosome
caspase 9
ICAD lamin
death
substrates vimentin actin
etc.
Figure 9.34 The Biology of Cancer (O Garland Science 2014)
Transcribed Image Text:11. Explain the role of cytochrome c, Bax/Bac, Fas receptor-ligand, caspases, IGFBP3 in causing apoptosis of cells, based on the figures given below. death ligand cytotoxic cell death receptor plasma membrane -granzyme B executioner caspase 3 initiator caspase 8 procaspases caspase 8 caspase 10 tBid executioner Bid cytochrome c procaspases Apaf-1 apoptosome caspase 9 ICAD lamin death substrates vimentin actin etc. Figure 9.34 The Biology of Cancer (O Garland Science 2014)
IGF-1/2
IGFBP-3
Fasl
FAS
IGF-1R
PI3 kinase
p53
IGFBP-3
Akt/PKB
cell survival
/signals
Bad
caspase 8
apoptosome
active
inactive
caspase 10
FOXO3
Вах
active
inactive
executioner
IKB
caspases
active
inactive
death
substrates
Figure 9.35 The Biology of Cancer (O Garland Science 2014)
CC
Transcribed Image Text:IGF-1/2 IGFBP-3 Fasl FAS IGF-1R PI3 kinase p53 IGFBP-3 Akt/PKB cell survival /signals Bad caspase 8 apoptosome active inactive caspase 10 FOXO3 Вах active inactive executioner IKB caspases active inactive death substrates Figure 9.35 The Biology of Cancer (O Garland Science 2014) CC
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