2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable mechanism for the following conversion using proper electron pushing and reasonable chemistry. CHO NH₂ N-CO,Et -CO₂Et H H NaOH, aq EtOH R₂NH b. The following reaction is an example of Mannich reaction. Please write a reasonable mechanism. N H N-CO2Et CO,H R₂N H
2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable mechanism for the following conversion using proper electron pushing and reasonable chemistry. CHO NH₂ N-CO,Et -CO₂Et H H NaOH, aq EtOH R₂NH b. The following reaction is an example of Mannich reaction. Please write a reasonable mechanism. N H N-CO2Et CO,H R₂N H
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem
wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable
mechanism for the following conversion using proper electron pushing and reasonable chemistry.
CHO
NH₂
of me
N-CO,Et
-CO₂Et
NaOH, aq EtOH
R₂NH
b. The following reaction is an example of Mannich reaction. Please write a reasonable
mechanism.
HiH
N-CO,Et
-CO,H
H
R₂N
H](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F2721ccf2-fbe1-4868-87fa-588e33d78a8e%2F908c7f31-1264-4cbd-b581-0f6b108c039a%2Fy1ywar_processed.png&w=3840&q=75)
Transcribed Image Text:2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem
wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable
mechanism for the following conversion using proper electron pushing and reasonable chemistry.
CHO
NH₂
of me
N-CO,Et
-CO₂Et
NaOH, aq EtOH
R₂NH
b. The following reaction is an example of Mannich reaction. Please write a reasonable
mechanism.
HiH
N-CO,Et
-CO,H
H
R₂N
H
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