20 Carbamazepine tablets were found to weigh 10.000 g in total. The tablets were ground to a fine powder using a pestle and mortar. A 313.2 mg sample of the powder was boiled with 25ml ethanol for a few minutes. The hot mixture was stirred in a closed flask for 10 minutes and filtered through sintered glass. The flask and filter were washed with ethanol and the washings combined with the filtrate. The cooled mixture was made up to 100ml with ethanol (soln A). 5ml of the ethanol extract was diluted to 250ml with ethanol (soln B) and the absorbance of the resulting solution was found to be 0.598 absorbance units at a wavelength of 285nm. The A1%,1cm was 490? a) Calculate the total amount (in mg) of carbamazepine in solution B (1 decimal) Answer = mg b) Calculate the total amount (in mg) of carbamazepine in solution A (1 decimal) Answer = mg C) Calculate the amount (in mg) of carbamazepine in a single tablet. (1 decimal) Answer =

20 Carbamazepine tablets were found to weigh 10.000 g in total. The tablets were ground to a fine powder using a pestle and mortar. A 313.2 mg sample of the powder was boiled with 25ml ethanol for a few minutes. The hot mixture was stirred in a closed flask for 10 minutes and filtered through sintered glass. The flask and filter were washed with ethanol and the washings combined with the filtrate. The cooled mixture was made up to 100ml with ethanol (soln A). 5ml of the ethanol extract was diluted to 250ml with ethanol (soln B) and the absorbance of the resulting solution was found to be 0.598 absorbance units at a wavelength of 285nm. The A1%,1cm was 490? a) Calculate the total amount (in mg) of carbamazepine in solution B (1 decimal) Answer = mg b) Calculate the total amount (in mg) of carbamazepine in solution A (1 decimal) Answer = mg C) Calculate the amount (in mg) of carbamazepine in a single tablet. (1 decimal) Answer =

Macroscale and Microscale Organic Experiments

7th Edition

ISBN:9781305577190

Author:Kenneth L. Williamson, Katherine M. Masters

Publisher:Kenneth L. Williamson, Katherine M. Masters

Chapter7: Extraction

Section: Chapter Questions

Problem 1Q

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5.1g of toothpaste was weighed out and transferred to a 500 ml beaker. 250 ml of deionized water was added to the beaker by measuring cylinder, heated for 5 minutes on a hotplate, then sonicated for 10 minutes in an ultrasonic bath. The contents of the beaker was then transferred to a 1000 ml volumetric flask, made to the mark with deionized water and mixed thoroughly. Ten ml of this solution was removed from the volumetric flask (autopipette), 5 ml (measuring cylinder) of TISAB buffer was added. The concentration of the toothpaste obtained is 3.4mgF-/L, calculate the % of fluoride (F) in toothpaste.
5.1g of toothpaste was weighed out and transferred to a 500 ml beaker. 250 ml of deionized water was added to the beaker by measuring cylinder, heated for 5 minutes on a hotplate, then sonicated for 10 minutes in an ultrasonic bath. The contents of the beaker was then transferred to a 1000 ml volumetric flask, made to the mark with deionized water and mixed thoroughly. 10 ml of this solution was removed from the volumetric flask (autopipette), 5 ml (measuring cylinder) of TISAB buffer was added. From the calibration curve of potential difference (mV) vs log[F-] equation, y = -56.21x - 151.71, the mean of [F-] is 1.81E-04 and the concentration in mgF-/L is 3.4. The expected Fluoride in toothpaste according to toothpaste manufacturer: 1000 ppm Fluoride. So how do i calculate the % of F in the toothpaste sample?
The concentration of purified OXA-M290 is tested with a BCA assay. Serial dilutions of a bovine serum albumin (BSA) stock solution are prepared, then pipetted into a 96-well plate; each dilution of the BSA standard is tested in triplicate. Then, bicinchoninic acid and Cu2+ ions are added to all of the wells of the plate. After incubating the plate for 1 hour, a microplate reader is used to measure the absorbance of all of the wells in the plate at 560 nm. This generates the following data: BSA conc. (μg/mL), Replicate 1 Absorbance, Replicate 2 Absorbance, Replicate 3 Absorbance 40, 1.360, 1.403, 1.481 20, 0.750, 0.745, 0.810 10, 0.380, 0.344, 0.398 5, 0.198, 0.160, 0.183 2.5, 0.090, 0.100, 0.085 1.25, 0.038, 0.043, 0.051 0.625, 0.024, 0.028, 0.019 Prepare a calibration curve using these data. You can use Excel, R, SPSS or an equivalent graphing software. In this graph, plot absorbance (y-axis) against the concentration of the protein standard (x-axis). Calculate and plot…
Oral rehydration salts are stated to contain the following components: Sodium Chloride 3.5g Potassium Chloride 1.5g Sodium Citrate 2.9g Anhydrous Glucose 20.0g 8.342 g of oral rehydration salts are dissolved in 500 ml of water. 5 ml of the solution is diluted to 100 ml and then 5 ml is taken from the diluted sample and is diluted to 100 ml. The sodium content of the sample is then determined by flame photometry. The sodium salts used to prepare the mixture were: Trisodium citrate hydrate (C6H5Na3O7, 2H2O) MW 294.1 and sodium chloride (NaCl) NW 58.5. Atomic weight of Na = 23. The content of Na in the diluted sample was determined to be 0.3210 mg/100 ml. Determine the % of stated content of Na in the sample. The stated should be 104.5, how??
Oral rehydration salts are stated to contain the following components: Sodium Chloride 3.5g Potassium Chloride 1.5g Sodium Citrate 2.9g Anhydrous Glucose 20.0g 8.342 g of oral rehydration salts are dissolved in 500 ml of water. 5 ml of the solution is diluted to 100 ml and then 5 ml is taken from the diluted sample and is diluted to 100 ml. The sodium content of the sample is then determined by flame photometry. The sodium salts used to prepare the mixture were: Trisodium citrate hydrate (C6H5Na3O7, 2H2O) MW 294.1 and sodium chloride (NaCl) NW 58.5. Atomic weight of Na = 23. The content of Na in the diluted sample was determined to be 0.3210 mg/100 ml. Determine the % of stated content of Na in the sample.
To determine the soil distribution coefficient (Kd), 10 g of dry soil is spiked with 100 mg of ring-labeled 14C-atrazine, 10 mL of deionized water is added, and the system is shaken for 24 hours. The aqueous and solid phases are separated, and the solid phase is extracted with 50 mL of methylene chloride while the aqueous phase is extracted with three successive 5 mL portions of methylene chloride. The atrazine concentration in the 50 mL of soil extract is 10 mg/L, and the concentration in the combined 15 mL from the aqueous extractions is 0.4 mg/L. Based on this information, calculate Kd.
1.063 g of p-acetamidophenol was measured out into a 50 mL round bottom flask along with 8 mL of 1M NaOH in ethanol and a stir bar. This mixture was heated at reflux for 15 min. It was allowed to cool and then 0.80 mL of bromoethane was added to the reaction. The mixture was then heated at reflux for another 15 min. After heating, the solution was poured onto a mixture of ice and water and further cooled on ice and then the solid was collected by vacuum filtration. This solid was then recrystallized from ethanol and water. The final mass of the purified phenacetin was 0.42250 g and it had a melting point of 127 - 130 C. The TLC plate shows (from left to right) pure p-acetamidophenol, the reaction mixture before pouring it on ice/water, phenacetin after recrystallization. The solvent used was a mixture of 80% ethyl acetate and 20% heptane with 0.5% acetic acid added. QUESTION: Using the given TLC plate can you describe the results and what does the TCL plate tell about the purity?
125.1 mg of streptomycin sulphate are dissolved in 10 ml of water. A GC headspace analysis is carried out in order to determine the methanol content of the drug. A peak for methanol is produced which has 73.2% of the area of a peak for a methanol standard containing 0.532 mg/100 ml of methanol in water analysed under exactly the same conditions, What is the methanol content of the streptomycin sulphate in ppm and %w/w? Answer: 311.3 ppm, 0.3113 % w/w.how??
A brewed tea brand sample was subjected to solvent extraction to extract caffeine. The cup of tea measuring 200 mL was extracted with petroleum ether. With KD = 20.0 (caffeine in pet ether-water), the % caffeine (194.10) extracted after 3 extractions with a total of 75.0 mL pet ether used is: A. 97.7% B. 28.6% C. 71.4% D. 2.33%
What volume (mL) of the prepared low alcoholic elixir is needed if the prescription requires 120 mL of an alcoholic elixir with 35% v/v alcoholic strength? Low alcoholic elixir alcoholic strength: 20% Low Alcoholic ElixirCompound Orange Spirit 10mLAlcohol 100mLGlycerin 200mLSucrose 320gPurified water, qs ad 1000mL High alcoholic elixir alcoholic strength: 79% High Alcoholic ElixirCompound Orange Spirit 4mLSaccharin 3gGlycerin 200mLAlcohol, qs ad 1000mL a 30.51 mL b 119.39 mL c 89.49 mL d 30.61 mL
. The total cation content of natural water is often determined by exchanging the cations for hydrogen ions on an ion exchange resin. The cations are adsorbed to the resin which releases H+ (1:1 exchange) which can then be titrated with a base. A 25.0 mL sample of a natural water is diluted to 100 mL with distilled water and 2.0 g of a cation-exchange resin was added. After stirring, the mixture was filtered and the solid remaining on the filter paper was washed with three 15.0 mL portions of distilled water. The filtrate and washing required 15.3 mL of 0.0202 M NaOH to reach the equivalence pt. Calculate the number of moles of cation present in 1.00 L of sample.
A scientist wishes to measure the concentration of methyl benzoate in a plant stream by gas chromatography. He prepares a sample of butyl benzoate to use as an internal standard. The results of a preliminary run, which used a solution known to contain 1.37 mg/mL of methyl benzoate (peak A) and 1.51 mg/mL of butyl benzoate (peak B), are shown. The area of peak A is determined to be 3.40×102 and the area of peak B is determined to be 398 measured in arbitrary units by the computer. To measure the sample, 1.00 mL of a standard sample of butyl benzoate containing 2.49 mg/mL is mixed with 1.00 mL of the plant stream material. Analysis of the mixture gave a peak area of 437 for peak A and 415 for peak B. What is the concentration of methyl benzoate in the plant stream?