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- For many years it was a complete mystery howcytotoxic T cells could see a viral protein that seemed to bepresent only in the nucleus of the virus-infected cell. Theanswer was revealed in a classic paper that took advan-tage of a clone of T cells whose T cell receptor was directedagainst an antigen assoicated with the nuclear protein ofthe 1968 strain of influenza virus. The authors of the paperfound that when they incubated high concentrations ofcertain peptides derived from the viral nuclear protein, thecells became sensitive to lysis by subsequent incubationwith the cytotoxic T cells. Using various peptides from the1968 strain and the 1934 strain (with which the cytotoxic Tcells did not react), the authors defined the particular pep-tide responsible for the T cell response (Figure Q24–1).A. Which part of the viral protein gives rise to thepeptide that is recognized by the clone of cytotoxic T cells? Why do not all viral peptides sensitize the target cells forlysis by the cytotoxic T…A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement.SYstemic Lupus erythematosus is an autoimmune disease in which antibodies are produced that target the person's own DNA. The DNA must be outside of the person's cell , in plasma and/ or interstitial space,in order antivodies to bind it. Immune resposes are thoght to be part of the cause of this aspect of lupus. Of the following which is moast likely to allow the preon's DNA to be exposed otside of cells? A, conversion of fibrinogen to fibrin B, Inflammation C, Complement Membrane Attack Complex D, Interferons E,Neutrophil Extracellular Traps
- At any given time, intestinal crypts of mice com-prise about 15 stem cells and 10 Paneth cells. After celldivision, which occurs about once a day, the daughtercells remain stem cells only if they maintain contact with aPaneth cell. This constant competition for Paneth-cell con-tact raises the possibility that crypts might become mono-clonal over time; that is, the crypt cells at one point in timemight derive from only 1 of the 15 stem cells that existedat some earlier time. To test this possibility, you use theso-called confetti marker that upon activation expressesany one of three fluorescent proteins in the stem cells ofthe crypt. You then examine crypts at various times todetermine whether they contain cells with multiple colorsor only one color (Figure Q22–1). Do the crypts becomemonoclonal over time or not? How can you tell?One important role of Fas and Fas ligand is to medi-ate the elimination of tumor cells by killer lymphocytes.In a study of 35 primary lung and colon tumors, half thetumors were found to have amplified and overexpressed agene for a secreted protein that binds to Fas ligand. How doyou suppose that overexpression of this protein might con-tribute to the survival of these tumor cells? Explain yourreasoning.B cells are specialized blood cells that secrete antibodies. Normally, human blood has millions of differenttypes of B cells making millions of different kinds ofantibody molecules. This variety occurs because, as described in the Fast Forward Box in Chapter 13 entitledProgrammed DNA Rearrangements and the ImmuneSystem, antibody genes undergo rearrangements in theprecursors of B cells. Individual B cell precursorsrearrange their antibody genes in different ways.In the blood of patients with cancers called B celllymphomas, almost all of the antibody molecules areall of one type, but this single type of antibody isdifferent in different lymphoma patients.a. Based on this information, provide a brief description of the genesis of B cell lymphomas, focusingon the cells that are overproliferating.
- 46) FcRn are essential for: a) reducing immune inflammation after acute infection b) increasing mast cell activation c) camel immune homeostasis d) absorption of IgG by infants e) none of these 47) An example of a live attenuated viral vaccine currently produced is: a) HIV b) Anthrax c) Polio d) cholera e) all of these 48) C8 is consider: a) an essential early protein in the complement cascade b) an essential late protein in the complement cascade c) an optional early protein in the complement cascade d) an optional late protein in the complement cascade e) more than one of these 49) Mycobacterium often escape CMI by: a) inhibiting TAP b) producing IL-10 c) inhibiting MHC class I production d) destroying NK cells e) inhibiting phagolysosome fusion 50) IL-4 is essential for B cells to switch to: a) IgA b) IgG c) laE d) IgD e) IgMyou need a flu shot every year/season because (HA-haemoagglutinin; NA-neuroaminidase) A) the virus can change its HA and NA every year, so a new shot is needed to teach your immune system how to recognize the changed HA and NA B) flu virus gets rid of its HA and NA and replace them with completely new ones every year C) your immune system weakens after a year-so you have to get another shot to get the system strong enough to attack the virus D)antigen shift occurs every yearAll nucleated cells in the body present antigens to___________T cells via the ______________ complex. Antigen recognition results in maturation of these T cells, which _______________ the cell that activated them. *I'm guessing the second blank is histocompatibility?
- Immune System (A&P II) In humans, the mother's antibodies do not cross from the baby's gut into the bloodstream. Yet human breast milk contains antibodies and does protect against intestinal infections. Discuss how these antibodies might work.Tuberculosis is a chronic respiratory condition caused by Mycobacterium tuberculosis, a high contagious bacterium. People with tuberculosis will often have a persistent (sometimes bloody) cough, fatigue, weight loss, and fever. M. tuberculosis produces a protein we will call “X”. A new test for tuberculosis checks for X antibodies in a person’s blood. If the antibodies are present, the result is “positive.” Why would X antibodies be present in someone’s blood? What specific kind of cells would produce them?The white blood cells known as T lymphocytes respond to antigens thatbind specifi cally to the T cell receptor, which consists of an antigen-binding αβ transmembrane protein as well as a set of transmembrane signaltransducing proteins known as CD3 that are targets of NRTKs. Thecytoplasmic domains of the CD3 proteins are positively charged and, in the absence of antigen, interact with the intracellular surface of the plasma membrane in such a way that buries several of their Tyr residues in the lipidbilayer. Antigen binding to the T cell receptor leads to a localized infl ux ofCa2+ ions. (a) Explain how a high concentration of Ca2+ could promote phosphorylation and activation of the CD3 proteins. (b) Would this henomenon make the T lymphocyte more or less responsive to the antigen?