31 What is the rate-determining step in the alkaline hydrolysis of an amide (reaction shown below) NH₂ H₂O/OH- he at A. Bonding of OH- nucleophile to carbonyl carbon. + B. Ejection of NH₂ from a tetrahedral intermediate. C. Protonation of an -NH₂ group in a tetrahedral intermediate. D. Ejection of NH3 from a tetrahedral intermediate. NH3

Pushing Electrons
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ISBN:9781133951889
Author:Weeks, Daniel P.
Publisher:Weeks, Daniel P.
Chapter3: Mechanisms
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31 What is the rate-determining step in the alkaline hydrolysis of an amide (reaction shown
below)
NH₂
H₂O/OH-
he at
+
A. Bonding of OH- nucleophile to carbonyl carbon.
B.
Ejection of NH₂ from a tetrahedral intermediate.
C. Protonation of an -NH₂ group in a tetrahedral intermediate.
D. Ejection of NH3 from a tetrahedral intermediate.
NH3
Transcribed Image Text:31 What is the rate-determining step in the alkaline hydrolysis of an amide (reaction shown below) NH₂ H₂O/OH- he at + A. Bonding of OH- nucleophile to carbonyl carbon. B. Ejection of NH₂ from a tetrahedral intermediate. C. Protonation of an -NH₂ group in a tetrahedral intermediate. D. Ejection of NH3 from a tetrahedral intermediate. NH3
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