4. A certain marker has genotype of AA or AB. A study with 150 individuals (half of them sick) has been conducted, and the genetic odds ratio calculated was 4. Two third of the case individuals have the AB genotype and the rest have AA genotype. Use x2 test to compute the LOD score and the P-value for assessing the association between the SNP and the disease phenotype.

4. A certain marker has genotype of AA or AB. A study with 150 individuals (half of them sick) has been conducted, and the genetic odds ratio calculated was 4. Two third of the case individuals have the AB genotype and the rest have AA genotype. Use x2 test to compute the LOD score and the P-value for assessing the association between the SNP and the disease phenotype.

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Description: 4. A certain marker has genotype of AA or AB. A study with 150 individuals (half of themsick) has been conducted, and the genetic odds ratio calculated was 4. Two third of thecase individuals have the AB genotype and the rest have AA genotype.Use 72

Biology: The Unity and Diversity of Life (MindTap Course List)

15th Edition

ISBN:9781337408332

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter14: Chromosomes And Human Inheritance

Section: Chapter Questions

Problem 3SQ: A recognized set of symptoms that characterize a genetic disorder is a(n) _______. a. syndrome b....

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4. Define the following terms: A. genotype B. phenotype C. monohybrid D. dihybrid
The forked line and probability methods make use of what probability rule? test cross product rule monohybrid rule sum rule
Variation in _____ is the basis of variation in traits. a. karyotype b. the DNA sequence c. the double helix d. chromosome number
1. The frequency of a recessive disease is 9%. What is the frequency of the allele that causes s the disease? a) What is the frequency of the dominant allele? b) What is the frequency of the carriers (heterozygotes) of the disease?
1. a) If you were at risk of a fatal disease such as Huntington’s disease and only the 95% accurate preliminary genetic test was available, would you take the test? After all, 95% of the time the test would tell you whether you would eventually get Huntington’s disease or whether you did not have to worry about getting this disease. b) The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?
4) A testcross is used to determine which of the following? a) The phenotype of an individual with a dominant genotype b) The phenotype of an individual with a recessive genotype c)The genotype of an individual with a dominant phenotype d) The genotype of an individual with a recessive phenotype
1. Suppose that the three samples are from two parents and their child. Which individuals are the parents? Which individual is the child? How do you know? Parent 1 = Parents 2 = Child = 2. What genotype must each individual have for this scenario to be possible? Parent 1 = Parent 2 = Child = please answer all of them now.
2. Be able to compare and contrast (discuss similarities and differences in) in your own words the terms genotype and phenotype, wild-type and mutant phenotypes. Step by step.
16.A couple is suspecting that their baby was switched at the hospital. The mother has blood type A, the father has blood type B, and the baby has blood type O. Which among the following conditions would prove that the baby is switched? A. Mother’s genotype: IAIA & Father’s genotype: ii B. Mother’s genotype: ii & Father’s genotype: IBIB C. Mother’s genotype: IAIA & Father’s genotype: IBIB D. Mother’s genotype: IAi & Father’s genotype: IBi
5.) A man and a woman living in a tropical area where malaria is prevalent and health care is not accessible have seven children during their lifetime. The genotypes of their children are: ss, Ss, SS, ss, Ss, Ss, and SS. What must the genotypes of both parents be? Your answer should include a Punnett square to illustrate your work, and list all the genotypes and phenotypes.
1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. People taking the test were classified as to whether they had the DNA sequence that was linked to the Huntington’s disease. This method was 95% accurate. This means that 95% of the people who had the Huntington’s-linked DNA sequence actually inherited the Huntington allele. It also meant that 95% of the people who did not have the DNA sequence linked to the Huntington allele did not inherited the wild-type allele (not the Huntington allele).Why might this preliminary test not be as accurate as a gene test for the actual Huntington’s allele? Explain.
Which recombination frequency corresponds to independent assortment and the absence of linkage? 0 0.25 0.50 0.75