5. Calculate km and Vmax of the following graphs. Y-axis is the initial rate (uM/min)
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- Vo 0 1 1.5 2 2.5 2.7 2.8 2.9 4 3 H.W/// Calculate Vmax and Km and draw the chart depending on the following information [s] 0 0.5 1 1.5 2 2.5 3 3.5 INWhich of the following can be obtained from a flow-volume loop study? 1. FVC 2. PEFR 3. FEVT 4. FEF 25%-75% A. 1 and 2 only B. 2 and 3 only C. 1,3 and 4 only D. 1,2,3, and 4Determine the % inaccuracy by calculating the percent error of the micropipette at the set volume of 100 µL A. Standard deviation B. Covieffecrnt of varaiant C. % error (precision) Percent error = mean volume delivered -expected volume x 100 Expected volume RUN Weight Measurement (in g) 1 0.0985 2 0.0987 3 0.0985 4 0.0982 5 0.0984 6 0.0984 7 0.0981 8 0.0983 9 0.0982 10 0.0988 Total 0.9841 A. Standard deviation B. Covieffecrnt of varaiant C. % error (precision)
- p02 Y O2 (mmHg) 0.5 0.161 1 0.277 0.434 3 0.535 4. 0.605 0.697 0.754 12 0.821 20 0.885 Using the data provided in the table, the estimated p50 for myoglobin is mmHg and the fraction saturation of myoglobin at 30mmHg is 6Calculate the hemoglobin concentration of an unknown sample given the following info: concentration of known = 12.5 g/dl; absorbance of unknown = 0.48; absorbance of known = 0.65 a. 16.9 g/dl b. 9.2 g/dl c. 8.7 g/dl d. 11.3 g/dl e. 10.4 g/dl11. Calculate KM and Vmax from the following data: [S] (µM) 0.1 0.2 0.4 0.8 1.6 vo (mM.s¯¹) 0.34 0.53 0.74 0.91 1.04
- The following data describe the binding of oxygen to human myoglobin. Posygen (mm Hg) Percent Saturation 0.5 16.1 2.0 27.7 3.0 53.5 4.0 60.5 6.0 69.7 8.0 75.4 12.0 82.1 20.0 88.5 From these data the approximate P50 (mm Hg) value is: A. 1.0 В. 1.4 С. 1.9 D. 2.6 Е. 3.2 F. 3.5 G. 3.7 Н. 3.9 I. 4.0When determining CFUs for a dilution of the same sample at 10-2 and 10-3 which of the following results would seem the most accurate to you? Explain why in the space below. A. 110,000 CFU/mL for 10-2; and 140,000 CFU/mL 10-3 B. 110,000 CFU/mL for 10-2; and 14,000 CFU/mL 10-3 C. 10,000 CFU/mL for 10-2; and 140,000 CFU/mL 10-3 D. none of the aboveDARK DARK CHOCOLATE A CHOCOLATE B Average systolic reading (mmHg) 117 110 68% of area Calculated value of 95% of area "1" Standard.Dev. + 3.38 + 7.97 (mmHg) 99.7% of area -3 -2 -1 For normally distributed data: 68% of the individual data values are within + "1" standard deviation of the mean. 95% of the individual data values are within + "2" standard deviations of the mean 99% of the individual data values are within + "3" standard deviations of the mean The values listed in the table above are for + "1" standard deviation. Add and subtract these 0thb values to and from the sample mean to gain a better appreciation for the blood pressures of the 09to975 individuals in each study. 811 values from the table above to Chocolate A: 68% of individuals had a blood pressure reading of (117 – 3.38) (117 + 3.38) 95% of individuals had a blood pressure reading of *+2 standard deviations, or twice the reported value to (117- 6.76) (117 + 6.76) use the values for tChocolate B: 68% of individuals…
- A 60 kg patient is on a continuous IV constant rate infusion of theophylline at 30 mg/h. His steady-state concentration is determined to be 12 mg/L. If you assume the theophylline distribution volume to be 22 L, what would be the patients plasma concentration 4 hours after the continuous infusion stopped? Please select one: 0 a. 6.5 mg/L b. 7.6 mg/L c. 4.8 mg/L d. 8.4 mg/L e. 3.7 mg/LWhen 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?Following administration of a single LV. bolus dose of 400 mg of drug Y, Cp° was 20 mg/L and Cp was 4.75 mg/L, calculate elimination rate constant (Kel). Select one: O a. 1.25/hr O b. 0.055/hr Oc. None of the above O d. 0.14/hr O e. 0.24/hr
