The following data describe the binding of oxygen to human myoglobin.Posygen (mm Hg)Percent Saturation0.516.12.027.73.053.54.060.56.069.78.075.412.082.120.088.5From these data the approximate P50 (mm Hg) value is:A. 1.0В. 1.4С. 1.9D. 2.6Е. 3.2F. 3.5G. 3.7Н. 3.9I.4.0

Oxygen is very much essential for life processes. The air we breathe contains oxygen which is…

Answered: The following data describe the binding…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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Which of the following statements about the oxygen-binding curves is FALSE? Select one: a. During normal activity (not exercising) the blood PO2 rarely falls below 40 mmHg. b. The PO2 and hemoglobin dissociation curve for myoglobin is to the left of fetal hemoglobin. c. The blood returning to the lungs is still 75% saturated with oxygen. d. A larger decrease in PO2 is needed for hemoglobin to drop from 100% to 75% O2 capacity than from 75% to 50% O2 capacity. e. During high metabolic activity the PO2 and hemoglobin dissociation curve would be expected to shift to the left of normal.
After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?
The oxyhemoglobin dissociation (saturation) curve shifts to the right as the blood becomes more acidic. Under these conditions answer the following. At a P O2 = 40 mmHg the percent saturation of hemoglobin __________ and the content of oxygen bound to hemoglobin ____________. A. Decreases; decreases B. Increases; increases C. Increases; decreases D. Decreases; increases E. Does not change; does not change
Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m),and you begin to ponder the “big questions,” such as “What is the fractionalsaturation of the Dalai Lama’s hemoglobin?”(a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2,and a P50 = 31 mm Hg, calculate the change in fractional O2 saturationof his hemoglobin going from his lungs (where PO2 = 85 mm Hg) to hiscapillaries (where PO2 = 25 mm Hg).(b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher thannormal (where “normal” = 27 mm Hg)?
Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m), and you begin to ponder the “big questions,” such as “What is the fractional saturation of the Dalai Lama’s hemoglobin?” a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2, and a P50 = 31 mmHg, calculate the change in fractional O2 saturation of his hemoglobin going from his lungs (where PO2 = 85 mmHg) to his capillaries (where PO2 = 25 mmHg). b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher than normal (where “normal” = 27 mmHg)?
During strenuous exercise, the oxygen-hemoglobin dissociation curve shifts to the right. This rightward shift reflects an increase in the affinity of hemoglobin for oxygen and favors loading of O2 onto hemoglobin in the lungs
When we change altitude, during the next few days, the body responds by adjusting Hb cooperativity. This can be accomplished by changing the concentration of 2,3-BPG in the blood. After moving from a low altitude to a higher altitude, does 2,3,-BPG increase or decrease? Explain how this affects oxygen transport capacity
The steep part of the O2-Hb dissociation curve... a. is where CO2 unloading occurs at the tissue cells b. is where the PO2 is high (>90mmHg) c. is where the oxyhemoglobin is high (>90 % saturated) d. is where O2 unloading occurs at the tissue cells
Anadult mouse has a respiratory rate of∼163 breaths/min and a tidal volumeof∼0.15 ml at BTP (37 ◦C) [36]. The averageO2 consumption for one strainof male adult mice is 45.5 ml O2/hour at STP. For the inspired aircomposition shown in Table 7.7, compute the expired air composition. Youmay assume that the ratio of CO2 production/O2 consumption is the samefor humans and mice
Which of the following will cause the largest increase in systemic arterial oxygen saturation in the blood?a. an increase in red cell concentration (hematocrit) of 20%b. breathing 100% O2 in a healthy subject at sea levelc. an increase in arterial PO2 from 40 to 60 mmHgd. hyperventilation in a healthy subject at sea levele. breathing a gas with 5% CO2, 21% O2, and 74% N2 at sea level
What is the effect of the following changes on the O2 affinity of myoglobin and hemoglobin? (a) A drop in the pH of blood plasma from 7.4 to 7.2. (b) A decrease in the partial pressure of CO2 in the lungs from 6 kPa (holding one’s breath) to 2 kPa (normal). (c) An increase in the BPG level from 5 mM (normal altitudes) to 8 mM (high altitudes).
In carbon monoxide (CO) poisoning, CO binds to hemoglobin, therebydecreasing the uptake of O2 by hemoglobin. In addition, when CO bindsto hemoglobin, the oxygen-hemoglobin dissociation curve shifts to theleft. How does this shift affect the ability of tissues to get O2? Explain

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