5. Examine the graphic below and answer the questions about the enzyme we reviewed in lecture. 1.0 0.01 mM Vo АТР Vmax 1 mM ATP 0.5 1 mM ATP + 0.1 mM AMP 1 [Fru-6-P] (mM) 2 A) What enzyme is this? What reaction does it perform? Of what metabolic pathway is this enzyme a part? B) What allosteric regulator, shown on the graph as presented here, is considered to be a homotropic allosteric factor? C) Which allosteric regulator, shown on the graph as presented here, has the greatest influence on this enzyme? Explain the reasoning behind your answer. D) Name a positive allosteric effector of this enzyme NOT shown on the graph as presented here. What is the origin of this positive allosteric effector..that is, where is it coming from? E) Name a negative allosteric effector of this enzyme NOT shown on the graph as presented here. What is the origin of this negative allosteric effector,..that is, where is it coming from? F) Explain how the regulation of this enzyme is tied to the "energy state" of the cell.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
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Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
Section: Chapter Questions
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5. Examine the graphic below and answer the questions about the enzyme we reviewed in lecture.
1.0
0.01 mM
Vo
Vmax
ATP
1 mM ATP
0.5
1 mM ATP
+ 0.1 mM AMP
1
[Fru-6-P]
(mM)
2
A) What enzyme is this? What reaction does it perform? Of what metabolic pathway is this enzyme a part?
B) What allosteric regulator, shown on the graph as presented here, is considered to be a homotropic allosteric
factor?
C) Which allosteric regulator, shown on the graph as presented here, has the greatest influence on this enzyme?
Explain the reasoning behind your answer.
D) Name a positive allosteric effector of this enzyme NOT shown on the graph as presented here. What is the
origin of this positive allosteric effector...that is, where is it coming from?
E) Name a negative allosteric effector of this enzyme NOT shown on the graph as presented here. What is the
origin of this negative allosteric effector...that is, where is it coming from?
F) Explain how the regulation of this enzyme is tied to the "energy state" of the cell.
Transcribed Image Text:5. Examine the graphic below and answer the questions about the enzyme we reviewed in lecture. 1.0 0.01 mM Vo Vmax ATP 1 mM ATP 0.5 1 mM ATP + 0.1 mM AMP 1 [Fru-6-P] (mM) 2 A) What enzyme is this? What reaction does it perform? Of what metabolic pathway is this enzyme a part? B) What allosteric regulator, shown on the graph as presented here, is considered to be a homotropic allosteric factor? C) Which allosteric regulator, shown on the graph as presented here, has the greatest influence on this enzyme? Explain the reasoning behind your answer. D) Name a positive allosteric effector of this enzyme NOT shown on the graph as presented here. What is the origin of this positive allosteric effector...that is, where is it coming from? E) Name a negative allosteric effector of this enzyme NOT shown on the graph as presented here. What is the origin of this negative allosteric effector...that is, where is it coming from? F) Explain how the regulation of this enzyme is tied to the "energy state" of the cell.
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