CASE STUDY #2A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to beseverely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “bloodproblem" in her family but doesn't know for sure. Her hemoglobin electrophoresis was normal, andthe complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cellOn the peripheral smear, there are many bizarre erythrocytes, includingcounts are normal.spiculated cells. A diagnosis of pyruvate kinase deficiency is made.5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates abovepyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not bemade in the appropriate amounts in the RBC because of the deficiency of pyruvateA. GlucoseB. OxaloacetateC. acetyl-CoAD. LactateExplanation for answer in no. 5:?

Pyruvate kinase is an glycolytic enzyme, which catalyzes the conversion of phosphoenolpyruvate (PEP)…

Answered: 5. Since in this patient pyruvate…

Surgical Tech For Surgical Tech Pos Care

5th Edition

ISBN:9781337648868

Author:Association

Publisher:Association

Chapter9: Surgical Pharmacology And Anesthesia

Section: Chapter Questions

Problem 9.3CS

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5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate ?