2. (: A diagram of the residues defining the binding site of 2,3-bis-phosphoglycerate (BPG) is shown on the right. Given the mutation in Hb Great Lakes, Leu(B68)His, show on either O2 binding plot whether its p(O2)50% will be altered in the presence of a 10-fold excess of BPG and in which direction with respect to that of HbA. Explain.

2. (: A diagram of the residues defining the binding site of 2,3-bis-phosphoglycerate (BPG) is shown on the right. Given the mutation in Hb Great Lakes, Leu(B68)His, show on either O2 binding plot whether its p(O2)50% will be altered in the presence of a 10-fold excess of BPG and in which direction with respect to that of HbA. Explain.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter25: Nitrogen Acquisition And Amino Acid Metabolism

Section: Chapter Questions

Problem 20P: Consider the synthesis and degradation of tyrosine as shown in Figures 25.37, 25.38, and 25.48 to...

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