7.7.3 Zinc sulfate eye drops Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are supposed to analyse the API in these tablets following standard quality assurance guidelines. Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30]. Research the type of titration described. Describe the chemical structure of any reagents involved in the analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11). Formulate the relevant chemical equations. (a) (b) (c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9. This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30]. For each titration, the following volume of edetate solution has been used:
7.7.3 Zinc sulfate eye drops Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are supposed to analyse the API in these tablets following standard quality assurance guidelines. Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30]. Research the type of titration described. Describe the chemical structure of any reagents involved in the analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11). Formulate the relevant chemical equations. (a) (b) (c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9. This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30]. For each titration, the following volume of edetate solution has been used:
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![7.7.3 Zinc sulfate eye drops
Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use
is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to
analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are
supposed to analyse the API in these tablets following standard quality assurance guidelines.
Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of
the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30].
(a) Research the type of titration described. Describe the chemical structure of any reagents involved in the
analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11).
(b) Formulate the relevant chemical equations.
(c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the
titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9.
This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30].
For each titration, the following volume of edetate solution has been used:](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F048526de-3532-488b-8021-9a7f4cf4b858%2F953add63-7b1f-4e5c-b010-751776cd9b2e%2F50f4otg_processed.png&w=3840&q=75)
Transcribed Image Text:7.7.3 Zinc sulfate eye drops
Zinc sulfate solution has been traditionally used as an astringent and a mild antiseptic. Nowadays, its use
is limited. Your pharmaceutical analysis company has been contacted by an important client and asked to
analyse a batch of eye drops containing zinc sulfate (ZnSO4). The description of your brief states that you are
supposed to analyse the API in these tablets following standard quality assurance guidelines.
Typical analysis methods used for quality purposes are based on titration reactions. A certain volume of
the eye drops is diluted and typically titrated with ammonium edetate using morbant black as indicator [30].
(a) Research the type of titration described. Describe the chemical structure of any reagents involved in the
analysis. You might want to familiarise yourself with the concept of chelation (see Chapter 11).
(b) Formulate the relevant chemical equations.
(c) The package states that each sterile solution contains 0.25% w/v of zinc sulfate heptahydrate. For the
titration, 5 ml of the zinc sulfate solution is diluted and an ammonia buffer is added to achieve pH 10.9.
This solution is titrated with 0.01 M disodium edetate and mordant black as indicator [30].
For each titration, the following volume of edetate solution has been used:
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