A 60-year-old woman who weighs 75kg requires a loading dose of an antibiotic to treat an infection. A plasma concentration of 4.5 mg/L of the antibiotic needs to be achieved for optimal therapeutic effectiveness. The volume of distribution (Vd) of this antibiotic is 0.2 L/kg. The salt factor (S) is 0.6 and bioavailability fraction (F) is 1. The antibiotic is available as a 100 mg/mL infusion. Loading dose = Amount of drug in the body Bioavailability (F) x Salt fraction (S) Amount of drug in the body = Target conc. (C) x Volume of distribution (Vd) How many millilitres of antibiotic infusion need to be administered? State your answer to 1 decimal place. unit- ml
A 60-year-old woman who weighs 75kg requires a loading dose of an antibiotic to treat an infection. A plasma concentration of 4.5 mg/L of the antibiotic needs to be achieved for optimal therapeutic effectiveness. The volume of distribution (Vd) of this antibiotic is 0.2 L/kg. The salt factor (S) is 0.6 and bioavailability fraction (F) is 1. The antibiotic is available as a 100 mg/mL infusion. Loading dose = Amount of drug in the body Bioavailability (F) x Salt fraction (S) Amount of drug in the body = Target conc. (C) x Volume of distribution (Vd) How many millilitres of antibiotic infusion need to be administered? State your answer to 1 decimal place. unit- ml
Chapter11: Properties Of Solutions
Section: Chapter Questions
Problem 109AE: Patients undergoing an upper gastrointestinal tract laboratory test are typically given an X-ray...
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A 60-year-old woman who weighs 75kg requires a loading dose of an antibiotic to
treat an infection. A plasma concentration of 4.5 mg/L of the antibiotic needs to be
achieved for optimal therapeutic effectiveness. The volume of distribution (Vd) of this
antibiotic is 0.2 L/kg. The salt factor (S) is 0.6 and bioavailability fraction (F) is 1. The
antibiotic is available as a 100 mg/mL infusion.
Loading dose = Amount of drug in the body
Bioavailability (F) x Salt fraction (S)
Amount of drug in the body = Target conc. (C) x Volume of distribution (Vd)
How many millilitres of antibiotic infusion need to be administered?
State your answer to 1 decimal place.
unit- ml
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