A confirmed case of systemic lupus erythematosus (SLE) with lupus associated nephritis has been admitted to the hospital. The follow-up ELISA to detect various autoantibodies suggests very high titres of anti-C1q autoantibodies. Explain How would you design your C1q-dependent haemolytic assay using this patient’s serum? How would you explain your results if you achieve a normal CH50 value? How would you explain your results if you fail to achieve a CH50 value

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter14: Formula Method
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A confirmed case of systemic lupus erythematosus (SLE) with lupus associated nephritis has been admitted to the hospital. The follow-up ELISA to detect various autoantibodies suggests very high titres of anti-C1q autoantibodies. Explain

How would you design your C1q-dependent haemolytic assay using this patient’s serum?

How would you explain your results if you achieve a normal CH50 value?

How would you explain your results if you fail to achieve a CH50 value?

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