A couple decide to have a child. They require and select a suitable sperm donor who they understand to be blood group AB and rhesus +ve. The carrier of the baby is blood group A and rhesus –ve. However, when the baby is born, they discover that the baby’s blood group is O rhesus +ve. Worried that there has been a mistake they ask for a DNA test, which confirms the sperm used was indeed that of the donor. Further DNA analysis of the carrier of the baby shows that she has isoagglutinogen alleles IA iO, while the baby is actually IB and IO. How would you explain the outcome of the blood group to the couple?What is the chance that any other children will be blood group O using the same sperm donor? What further medical considerations should the couple consider for this child and additionally for any other subsequent pregnancies?

The blood group of a person is decided by the presence or absence of particular antigens on the…

Answered: A couple decide to have a child. They…

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter19: Introduction To Genetics

Section: Chapter Questions

Problem 6CT: The ABO blood system has been used to settle cases of disputed paternity. Suppose, as a geneticist,...

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A couple decide to have a child. They require and select a suitable sperm donor who they understand to be blood group AB and rhesus +ve. The carrier of the baby is blood group A and rhesus –ve. However, when the baby is born, they discover that the baby’s blood group is O rhesus +ve. Worried that there has been a mistake they ask for a DNA test, which confirms the sperm used was indeed that of the donor. Further DNA analysis of the carrier of the baby shows that she has isoagglutinogen alleles I^A i^O, while the baby is actually I^B and I^O.

How would you explain the outcome of the blood group to the couple?

What is the chance that any other children will be blood group O using the same sperm donor?

What further medical considerations should the couple consider for this child and additionally for any other subsequent pregnancies?

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