A family from coastal Africa recently moved to Canada. Soon after the move, their 6-month-old baby starts napping more frequently and often cries as if in pain. Concerned, the parents take their baby to a pediatrician, who diagnoses the baby with Sickle Cell Disease. The parents are astonished; neither has Sickle Cell Disease nor do their parents or siblings. How could this be possible? Use your knowledge of Mendelian Genetics and patterns of Inheritance to explain how this baby has Sickle Cell Disease when neither parent exhibits this disease phenotype. What term(s) could be used to describe the genotype of the baby's parents? What term(s) could be used to describe the genotype of the baby with Sickle Cell Disease?

A family from coastal Africa recently moved to Canada. Soon after the move, their 6-month-old baby starts napping more frequently and often cries as if in pain. Concerned, the parents take their baby to a pediatrician, who diagnoses the baby with Sickle Cell Disease. The parents are astonished; neither has Sickle Cell Disease nor do their parents or siblings. How could this be possible? Use your knowledge of Mendelian Genetics and patterns of Inheritance to explain how this baby has Sickle Cell Disease when neither parent exhibits this disease phenotype. What term(s) could be used to describe the genotype of the baby's parents? What term(s) could be used to describe the genotype of the baby with Sickle Cell Disease?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy

Section: Chapter Questions

Problem 9QP: Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites...

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A woman with fair skin, blond hair, and blue eyes gives birth to fraternal twins; the father has dark brown skin, dark hair, and brown eyes. One twin has blond hair, brown eyes, and light skin, and the other has dark hair, brown eyes, and dark skin. What Mendelian law does this real-life case illustrate and explain what this means in terms of the inherited alleles for these genes?
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in own understanding, what is mendelian genetics?
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When Mendel did his experiments, it was the case that the genes for each trait were on separate pairs of homologous chromosomes. For example, the genes for pod color were on one pair of chromosomes and the genes for the seed coat were on a different pair of chromosomes. What if the genes for the two traits were on the same chromosome? (That is, if the gene for pod color was on the same chromosome as the gene for seed coat.) Would Mendel’s 2nd Law still hold? Why or why not?
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Gregor Johann Mendel carried out experiments with pea plants that demonstrated how certain physical traits were passed down from one generation to the next in a predictable pattern. He introduced the concepts of dominant and recessive traits and established fundamental laws of inheritance for what is known as Mendelian Genetics. A trait can be inherited when each parent passes down one copy of a gene. Different versions of the same gene are known as alleles. Both gene copies are an organism’s genotype, and the physical expression of those genes is a phenotype. 1. Explain one of the three laws of inheritance proposed by Mendelian genetics. Mendelian inheritance can be visualized using Punnett squares. The first row and column represent the parental alleles, while the squares predict the possible combination of alleles of the resulting offspring. Dominant alleles are indicated by uppercase letters while recessive alleles are indicated by lowercase letters. The combination of alleles in…
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?