A graduate student was assaying LD50 (lethal dose 50%) of two temperature-sensitive Francisella tularensis strains in HeLa cells (human cell line). Both strains can infect humans and cause fatal tularemia if untreated, but it is difficult to obtain LD50 values in human subjects. The data below shows LD50 (lethal dose 50%) values of the strains in human cell culture. Can you predict the more virulent strain of the two human pathogens?Francisella tularensis strain A: LD50 @ 20∘C= 100; LD50 @ 37∘C= 1000Francisella tularensis strain B: LD50 @ 20∘C= 1000 LD50 @ 37∘C= 100Group of answer choicesIt is not possible to determine the virulence of the two strains as human pathogens from the provided dataStrain A and strain B are equally virulent as human pathogens, as they average out in virulence.Strain A is more virulent than strain A as a human pathogen.Strain B is more virulent than strain A as a human pathogen.

Given:At 20°C: Strain A LD50 = 100, Strain B LD50 = 1000. At 37°C: Strain A LD50 = 1000, Strain B…

Answered: A graduate student was assaying LD50…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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A graduate student was assaying LD₅₀(lethal dose 50%) of two temperature-sensitive Francisella tularensis strains in HeLa cells (human cell line). Both strains can infect humans and cause fatal tularemia if untreated, but it is difficult to obtain LD₅₀values in human subjects. The data below shows LD₅₀(lethal dose 50%) values of the strains in human cell culture. Can you predict the more virulent strain of the two human pathogens?

Francisella tularensis strain A: LD₅₀@ 20∘C= 100; LD₅₀@ 37∘C= 1000

Francisella tularensis strain B: LD₅₀@ 20∘C= 1000 LD₅₀@ 37∘C= 100

Group of answer choices

It is not possible to determine the virulence of the two strains as human pathogens from the provided data

Strain A and strain B are equally virulent as human pathogens, as they average out in virulence.

Strain A is more virulent than strain A as a human pathogen.

Strain B is more virulent than strain A as a human pathogen.

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