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A laboratory research group did a microarray experiment five years ago with 10 subjects in the normal group, and 6 subjects in the diet group; one microarray per subject. They never published their results because they felt like their diet group was too small. Now they have more money and they want to get 4 diet animals, and run 4 new microarrays on those animals. They plan to add that data to their study so they can increase their statistical discovery power, and finally publish their results.   Although increasing the number of subjects should increase the statistical power of the study, give a reason why increasing the number of samples might NOT result in more significant results.

A laboratory research group did a microarray experiment five years ago with 10 subjects in the normal group, and 6 subjects in the diet group; one microarray per subject. They never published their results because they felt like their diet group was too small. Now they have more money and they want to get 4 diet animals, and run 4 new microarrays on those animals. They plan to add that data to their study so they can increase their statistical discovery power, and finally publish their results.   Although increasing the number of subjects should increase the statistical power of the study, give a reason why increasing the number of samples might NOT result in more significant results.

Linear Algebra: A Modern Introduction
Linear Algebra: A Modern Introduction
4th Edition
ISBN:9781285463247
Author:David Poole
Publisher:David Poole
Chapter7: Distance And Approximation
Section7.3: Least Squares Approximation
Problem 31EQ
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A laboratory research group did a microarray experiment five years ago with 10 subjects in the normal group, and 6 subjects in the diet group; one microarray per subject. They never published their results because they felt like their diet group was too small. Now they have more money and they want to get 4 diet animals, and run 4 new microarrays on those animals. They plan to add that data to their study so they can increase their statistical discovery power, and finally publish their results.

 

  1. Although increasing the number of subjects should increase the statistical power of the study, give a reason why increasing the number of samples might NOT result in more significant results. 

 

 

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