A loss-of-function mutation in the ion channel responsible for the generation of end-plate potentials results in a diminished permeability of the ion channel.  1)  How would you experimentally test the effect of the mutation on the functional properties of the cell (synapse)? You should discuss the types of postsynaptic responses and physiological parameters you could measure.

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
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Chapter39: Information Flow And The Neuron
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Problem 8TYK: Which of the following statements best describes saltatory conduction? a. It inhibits direct...
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A loss-of-function mutation in the ion channel responsible for the
generation of end-plate potentials results in a diminished permeability
of the ion channel. 

1)  How would you experimentally test the effect of the mutation on the
functional properties of the cell (synapse)? You should discuss the types
of postsynaptic responses and physiological parameters you could
measure.

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