iii and iv Sickle cell anemia is inherited as an autosomal recessive trait. For the following families,determine the genotypes of the parents and offspring. When two alternative genotypes arepossible, list both.(i)Two normal parents have six children, five normal and one with sickle cell anemia.(ii)A normal male and a female with sickle cell anemia have five children, all normal.(ii)A normal female and a male with sickle cell anemia have six children, three normaland three with sickle cell anemia.(iv)Two normal parents have six children, all normal.Construct a pedigree of the families in Ql a) (ii) and (iii). Assume that one of thenormal children in (ii) and one of the sickle cell anemia children in (iii) become theparents of four children. Extend the pedigree to include the four children in the thirdgeneration and predict their phenotypes.(v)

Sickle cell anemia and sickle cell disease is an inherited disorder that occurs due to a faulty…

Answered: A normal female and a male with sickle…

BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)

10th Edition

ISBN:9781305967359

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Chapter14: Human Inheritance

Section: Chapter Questions

Problem 4GP: An allele responsible for Marfan syndrome Section 13.4 is inherited in an autosomal dominant...

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Does the phenotype indicated by the red circles and squares in this pedigree show an inheritance pattern that is autosomal dominant, autosomal recessive, or X-linked?
An allele responsible for Marfan syndrome Section 13.4 is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the allele if one parent does not carry it and the other is heterozygous?
A man with thalassemia minor marries a normal woman. What phenotypic ratios of thalassemia-affected children might these parents expect?
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
A couple who are a carrier of sickle-cell disease with blood type A for the female and type B for the male (assume heterozygosity for blood types). What is the probability that they will have a son with blood type B and is sickle- cell? Please show the solution.
What is the most likely pattern of inheritance for this disorder? (Is it autosomal dominant? Autosomal recessive? X-linked dominant? X-linked recessive? Y-linked? Mitochondrial?) Please include two specific pieces of evidence, present within the pedigree, that indicate that this pattern is most likely, as opposed to any other potential pattern. You may assume that the gene responsible for the trait is fully penetrant.
Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor anemia or a major anemia. Assuming that only a single gene pair and two alleles are involved in the inheritance of these conditions, is thalassemia a dominant or recessive disorder?
Chands syndrome is an autosomal recessive condition characterized by very curly hair, underdeveloped nails, and abnormally shaped eyelids. In the pedigree below: Which individuals must be carriers (heterozygotes)? -----
Porphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.
In a disputed parentage case, the child is blood type O, while the mother is blood type A. What blood type would exclude a male from being the father? Would the other blood types prove that a particular male was the father?
Two normal parents have a child with cyatic fibrosis. Would this be an autosomal dominant or autosomal recessive disorder? What is the chance that their next child will have cystic fibrosis?
Albinism is a recessive disorder where there is a lack of melanin. Andrea and her husband Claude both have normal skin pigmentation. Andrea’s mother has the albino phenotype, but her father and her brother do not (normal pigmentation). Claude’s parents are both normal, but he has a sister who has the condition (is albino). Answer the following questions If Andrea and Claude are carriers for the albino allele, what is the probability that they have an albino child? If Andrea and Claude have a second child, what is the probability this child be normal (non-albino)? NOTE: Draw a punnet square or show your work.

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A normal female and a male with sickle cell anemi and three with sickle cell anemia. (iii) (iv) Two normal parents have six children, all normal.