One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. If your patient's parents decide to have another child, what is the chance that that child will also have sickle cell anemia? 0% 25% 50% 75% 100%

One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. If your patient's parents decide to have another child, what is the chance that that child will also have sickle cell anemia? 0% 25% 50% 75% 100%

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 18QP: Blood Types Are Determined by Cell-Surface Antigens A patient of yours has just undergone shoulder...

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One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain, and other severe complications. Patients with sickle cell anemia produce defective beta-globin due to a point mutation that causes the change of a single amino acid residue. This is an example of what type of mutation? nonsense mutation missense mutation frameshift mutation deletion mutation
Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?
Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.
interpret using the punnett square below to both sets of parents (Parents A , Parents B, & Parents C).based on your results of filling in the boxes. What are the chances Parents A, Parents B, and Parents C will have a child with Sickle Cell? What are the chances the child will be a carrier for Sickle Cell?
A normal woman marries a man with sickle-cell trait. What is the probability of their having a (a) child with sickle-cell trait, (b) normal child, (c) child with sickle cell anemia?
Henrietta Lacks was female, so, naturally, all the cells from her derived cancerous cell line have _______ chromosomes.
A man with type AB blood marries a woman with type A blood. Her mother has type O blood. What percentage of their children will have: Type A blood? __________ % Type B blood? __________ % Type AB blood? _________ % Type O blood? __________ %
Huntington’s Disease is a dominant lethal disease that manifests later in life after many people have had children. If you were the child of a parent who was diagnosed with Huntington's, would you want to be tested for the condition? Why or why not?
Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. Anthony and Melinda met at a support group for individuals who have hereditary hemochromatosis. They were advised by their genetic counselor that it would be risky to have children, since both of them are homozygous for the same recessive allele that causes this condition. Nevertheless, they decided to have a child together. During Melinda’s pregnancy, amniocentesis and genetic testing were performed, and it was confirmed the fetus was homozygous for the hereditary hemochromatosis allele. At birth, the baby appeared completely normal, and as the child continued to grow and mature, the couple were surprised that he seemed…
Barbara and John have two daughters (Madison and Kelly), and one son (Mike), all have normal red blood cells. Their other son (Chase) has been diagnosed with sickle cell. Barbara recently gave birth to another son (Barry) who also has been diagnosed with sickle cell. Barbara’s mother (Beth) has sickle cell, but her father (Jason), three sisters (Emma, Lori, and Allison), and two brothers (Emmitt and Will) are all normal. John’s father (Jim), mother (Brenda), and brother (Parker) are all normal, but his sister (Demi) has sickle cell. John’s maternal grandparents (Bill and Lonna) are carriers. Barbara’s paternal grandparents (Kevin and Martha) are all normal. make an pedigree
Barbara and John have two daughters (Madison and Kelly), and one son (Mike), all have normal red blood cells. Their other son (Chase) has been diagnosed with sickle cell. Barbara recently gave birth to another son (Barry) who also has been diagnosed with sickle cell. Barbara’s mother (Beth) has sickle cell, but her father (Jason), three sisters (Emma, Lori, and Allison), and two brothers (Emmitt and Will) are all normal. John’s father (Jim), mother (Brenda), and brother (Parker) are all normal, but his sister (Demi) has sickle cell. John’s maternal grandparents (Bill and Lonna) are carriers. Barbara’s paternal grandparents (Kevin and Martha) are all normal Paternal = a person’s dad’s side of the family Maternal = a person’s mom’s side of the family 1. Draw a pedigree to show how this trait could affect this family within each generation 2. Shade all individuals affected with the disorder. Half shade all carriers. 3. Assign genotypes to every individual. Use Punnett squares to…
__________ is the loss or gain of one or morechromosomes.