A peptide has the sequence Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–GlyGlu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side‑chain pKa glutamate 9.609.60 2.342.34 4.254.25 histidine 9.179.17 1.821.82 6.006.00 tryptophan 9.399.39 2.382.38 serine 9.159.15 2.212.21 glycine 9.609.60 2.342.34 leucine 9.609.60 2.362.36 arginine 9.049.04 2.172.17 12.4812.48 proline 10.9610.96 1.991.99
A peptide has the sequence Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–GlyGlu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side‑chain pKa glutamate 9.609.60 2.342.34 4.254.25 histidine 9.179.17 1.821.82 6.006.00 tryptophan 9.399.39 2.382.38 serine 9.159.15 2.212.21 glycine 9.609.60 2.342.34 leucine 9.609.60 2.362.36 arginine 9.049.04 2.172.17 12.4812.48 proline 10.9610.96 1.991.99
Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins
Section26.SE: Something Extra
Problem 34AP: Using both three- and one-letter codes for amino acids, write the structures of all possible...
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A peptide has the sequence
Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–GlyGlu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly
The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table.
Amino acid | Amino pKa | Carboxyl pKa | Side‑chain pKa |
---|---|---|---|
glutamate | 9.609.60 | 2.342.34 | 4.254.25 |
histidine | 9.179.17 | 1.821.82 | 6.006.00 |
tryptophan | 9.399.39 | 2.382.38 | |
serine | 9.159.15 | 2.212.21 | |
glycine | 9.609.60 | 2.342.34 | |
leucine | 9.609.60 | 2.362.36 | |
arginine | 9.049.04 | 2.172.17 | 12.4812.48 |
proline | 10.9610.96 | 1.991.99 |
Calculate the net charge of the molecule at pH 8
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