Organic And Biological Chemistry
7th Edition
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:STOKER, H. Stephen (howard Stephen)
Chapter9: Proteins
Section: Chapter Questions
Problem 9.57EP
Related questions
Question
A peptide has the sequence
Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly
The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table.
| Amino acid | Amino pKa | Carboxyl pKa | Side‑chain pKa |
|---|---|---|---|
| glutamate | 9.609.60 | 2.342.34 | 4.254.25 |
| histidine | 9.179.17 | 1.821.82 | 6.006.00 |
| tryptophan | 9.399.39 | 2.382.38 | |
| serine | 9.159.15 | 2.212.21 | |
| glycine | 9.609.60 | 2.342.34 | |
| leucine | 9.609.60 | 2.362.36 | |
| arginine | 9.049.04 | 2.172.17 | 12.4812.48 |
| proline | 10.9610.96 | 1.991.99 |
Calculate the net charge of the molecule at pH 11 and estimate the isoelectric point (pI)(pI) for this peptide.
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