A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image. B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein. C) Provide a detailed description of how each protein is held associated to the biological membrane. Protein 2 Protein 3 Protein 1 "H,N. Exterior Cytosol

A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image. B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein. C) Provide a detailed description of how each protein is held associated to the biological membrane. Protein 2 Protein 3 Protein 1 "H,N. Exterior Cytosol

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter3: Biological Macromolecules

Section: Chapter Questions

Problem 2VCQ: Figure 3.23 Which categories of amino acid would you expect to find on the surface of a soluble...

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Distinguish between transmembrane proteins, integral proteins, and peripheral proteins. 7. Integral proteins are often found spanning the membrane of a cell or organelle. These proteins serve as channels for specific molecules to travel through the membrane, either into or out of the cell. Indicate on the picture of the integral protein where you would most likely find amino acids with hydrophobic R-groups. Next, indicate on the picture of the integral protein where you would most likely find amino acids with hydrophilic R-groups. Explain your reasoning.
1. Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer. a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues that can be in each α-helixes for them to be long enough to span the bilayer? b. If one of the three α-helixes is titled at a 32° angle relative to an axis perpendicular to the surface of the lipid bilayer, what is the smaller number of amino acid helixes required for that helix to still span the lipid bilayer? c. How many hydrogen bonding interactions would there be in the smallest possible tilted transmembrane α-helix? d. If the tilted α-helix was a 310 helix instead how many amino acid residues would be required to span the lipid bilayer? How many amino acid residues would be required if it was a π-helix?
In the "fluid " _______ cell membrane model, lipids are organized in a ________ arrangement, such that _______ portions of the lipids are exposed to either the interior or exterior of the cell, while the lipid portions are sandwiched in the middle of the membrane. As part of the cell membrane, a main function of peripheral proteins is to provide _________ , while a main function of proteins is to provide _________ . Other cell membrane molecules include a compound called __________, which functions to provide fluidity to rigid membranes and rigidity to fluid membranes; and surface carbohydrates, which function in the membrane not to provide energy, but instead to provide _________ _____ . Aminophospholipids (including PE and ) move to the inner leaflet of the membrane, by an enzyme known as the ._______ A main function of the cell membrane is to be very selective as to what is able to cross through, a condition known as a barrier.
What TWO factors keep integral trans-membrane proteins embedded firmly within the lipid bilayer?
Transmembrane portrudes on both sides. Integral protein is in the width of the bilayer and may portrude on one or both sides of the bilayer. Is Transmembrane Protein semi-similar to Integral Proteins? How can we tell the difference of the two?
What typical structure[s] is/are found in integral membrane proteins – how do they span themembrane?
Biological membranes are critical components of cells that allow compartmentalisation of cellular contents. The diagram shows a biological membrane comprised of a lipid bilayer with a single polypeptide integrated into the membrane and spanning the membrane seven times. What types of amino acids are likely present in the parts of the polypeptide chain labelled 1-7 and in the parts of labelled A-G? What is the name of the effect that forces the polypeptide to arrange itself like this within the lipid bilayer? Give an example of a type of molecule that can move freely across the lipid bilayer and explain why it can do so based on its chemical properties.
The integral membrane protein XYZR has a single alpha helix spanning the membrane. Where was this protein made and what can you say about amino acids that occur/do not occur in the alpha helix versus the domains sticking out on both sides of the membrane?
To get an idea of the different sizes of various cellular components, do the following calculations: Assume that the cell, its nucleus, and a globular protein – for example, and enzyme – are spherical. In addition, assume the diameter of the protein is 5 nm (nanometers), the diameter of the cell is 100 μm (micrometers), and the diameter of the nucleus is 40 μm. You may have to review your metric conversions! If you draw the globular protein as a sphere with a diameter of 2 cm (approximately the diameter of a U.S. penny), what size would each of the following measurements of the cell be if drawn to the same scale (5 nm real length = 2 cm)? a. The radius of a microtubule, 15 nm b. The diameter of the nucleus c. The diameter of the cell d. The volume (V = 4/3 ∏r3) of the globular protein, in decimal form to the hundredths place. e. The volume of the nucleus f. The volume of the cell
Which of these structures would you expect to find as part of the transmembrane portion of an integral membrane protein? Structure B would be part of the transmembrane domain of an integral membrane protein. Structure C would be part of the transmembrane domain of an integral membrane protein. Structure A would be part of the transmembrane domain of an integral membrane protein.
The plasma membrane of E. coli is about 75% protein and 25% phospholipid by weight. How many molecules of membrane lipid are present for each molecule of membrane protein? Assume an average protein Mr of 50,000and an average phospholipid Mr of 750. What more would you need to know to estimate the fraction of the membrane surface that is covered by lipids?
Identify the following membrane associated proteins based on their structure: (a) tetramers of identical subunits, each with six membrane spanning α helices; (b) trimers of identical subunits, each with 16 β sheets forming a barrel like structure.