Collagen is the major structural protein for extracellular matrix, and it is also the most abundant protein in vertebrates. ECM consists of protein fibers and ground substance collagen's macromolecular structure consists of 3- coiled polypeptides called alpha chains, which are left-handed polypeptide helices and wind around right-handed triple helix. It also has 3.3 amino acid residue per turn. ECM consists of protein fibers and ground substance, which collagen's macromolecular structure would help leading it to function. Collagen's biophysical characteristics in extracellular matrix are acellular component and tissue and organs used collagen in cell morphogenesis and differentiation, which would help for maintaining homeostasis. Collagen also helps in glycosylation. EMC is usually secreted by the connective tissue cells and determines the tissue qualities. Formation of tropocollagen as it is fundamental unit of collagen and it is secreted in extracellular space, which helps in aggregation of fibrils. As collagen is a large family of proteins and it contains about 19 different members. The amino acid sequence is alpha chain and consist of repeating tripeptide unit as glycine, Proline and Hydroxyproline. The hydroxylation is carried out during post translational modifications of alpha chains by two enzymes prolyl hydroxylase and ysyl hydroxylase. So, by this its molecular composition impact these characteristics.
Collagen is the major structural protein for extracellular matrix, and it is also the most abundant protein in vertebrates. ECM consists of protein fibers and ground substance collagen's macromolecular structure consists of 3- coiled polypeptides called alpha chains, which are left-handed polypeptide helices and wind around right-handed triple helix. It also has 3.3 amino acid residue per turn. ECM consists of protein fibers and ground substance, which collagen's macromolecular structure would help leading it to function. Collagen's biophysical characteristics in extracellular matrix are acellular component and tissue and organs used collagen in cell morphogenesis and differentiation, which would help for maintaining homeostasis. Collagen also helps in glycosylation. EMC is usually secreted by the connective tissue cells and determines the tissue qualities. Formation of tropocollagen as it is fundamental unit of collagen and it is secreted in extracellular space, which helps in aggregation of fibrils. As collagen is a large family of proteins and it contains about 19 different members. The amino acid sequence is alpha chain and consist of repeating tripeptide unit as glycine, Proline and Hydroxyproline. The hydroxylation is carried out during post translational modifications of alpha chains by two enzymes prolyl hydroxylase and ysyl hydroxylase. So, by this its molecular composition impact these characteristics.
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter30: Protein Synthesis
Section: Chapter Questions
Problem 10P: The Consequences of Ribosome Complexity Eukaryotic ribosomes are larger and more complex than...
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Transcribed Image Text:Collagen is the major structural protein for extracellular matrix, and it is also the
most abundant protein in vertebrates. ECM consists of protein fibers and ground
substance collagen's macromolecular structure consists of 3- coiled polypeptides
called alpha chains, which are left-handed polypeptide helices and wind around
right-handed triple helix. It also has 3.3 amino acid residue per turn. ECM consists
of protein fibers and ground substance, which collagen's macromolecular
structure would help leading it to function.
Collagen's biophysical characteristics in extracellular matrix are acellular
component and tissue and organs used collagen in cell morphogenesis and
differentiation, which would help for maintaining homeostasis. Collagen also helps
in glycosylation. EMC is usually secreted by the connective tissue cells and
determines the tissue qualities. Formation of tropocollagen as it is fundamental
unit of collagen and it is secreted in extracellular space, which helps in aggregation
of fibrils.
As collagen is a large family of proteins and it contains about 19 different members.
The amino acid sequence is alpha chain and consist of repeating tripeptide unit as
glycine, Proline and Hydroxyproline. The hydroxylation is carried out during post
translational modifications of alpha chains by two enzymes prolyl hydroxylase and
lysyl hydroxylase. So, by this its molecular composition impact these
characteristics.
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