A. Starting from acetyl chloride and other compounds, show the mechanism leading to the formation of the following compounds. 1. Acetic acid 2. Acetic anhydride 3. N-methylacetamide

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Chapter1: Chemical Foundations
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EXERCISE. Submit a handwritten output during our face-to-face class. Write your answer in a
clean white paper.
CARBOXYLIC ACIDS AND THEIR FUNCTIONAL DERIVATES
Prepared by Arthur J. Lagbas, RCh
From the book of E.B. Rodriguez. Basic Principles of Organic Chemistry. 1997. UP Open University
A. Starting from acetyl chloride and other compounds, show the mechanism leading to the
formation of the following compounds.
1. Acetic acid
2. Acetic anhydride
3. N-methylacetamide
B. Show the mechanism of the formation of
CH3
from carboxylic acid and alcohol. Note: identify the carboxylic acid part and the alcohol part.
C. Show the mechanism of the acid-catalyzed hydrolysis and base-catalyzed hydrolysis of
aio
D. Show the mechanism of
CH₂
E. Starting from acyl chloride and other compounds show the synthesis of
as
NH₂
OH
OH
- of
heat
OH
F. Show the synthesis of Structure B from Structure A.
OH
ad
Structure A
CH₂
Structure B
G. An old bottle containing Structure B (see F) smell vinegar (acetic acid). Provide for a mechanistic
explanation.
Transcribed Image Text:EXERCISE. Submit a handwritten output during our face-to-face class. Write your answer in a clean white paper. CARBOXYLIC ACIDS AND THEIR FUNCTIONAL DERIVATES Prepared by Arthur J. Lagbas, RCh From the book of E.B. Rodriguez. Basic Principles of Organic Chemistry. 1997. UP Open University A. Starting from acetyl chloride and other compounds, show the mechanism leading to the formation of the following compounds. 1. Acetic acid 2. Acetic anhydride 3. N-methylacetamide B. Show the mechanism of the formation of CH3 from carboxylic acid and alcohol. Note: identify the carboxylic acid part and the alcohol part. C. Show the mechanism of the acid-catalyzed hydrolysis and base-catalyzed hydrolysis of aio D. Show the mechanism of CH₂ E. Starting from acyl chloride and other compounds show the synthesis of as NH₂ OH OH - of heat OH F. Show the synthesis of Structure B from Structure A. OH ad Structure A CH₂ Structure B G. An old bottle containing Structure B (see F) smell vinegar (acetic acid). Provide for a mechanistic explanation.
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