Additional practice at home: 1. Add NADH 2. Add ADP+Pi 3. Add deferoxamine mesylate (DFO), an iron chelator 4. Lower external pH by two pH units 5. Add DNP
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- TRUE OR FALSE 23. Increased temperature increases Km. 24. Competitive irreversible inhibitors cannot be displaced by the original substrate.What is the most dangerous adverse effect following use of biguanides?A. Lactic acidosisB. HypoglycaemiaC. Diabetic ketoacidosisD. HyperosmolalityE. HyperglycaemiaDiscuss the biochemical effects of acute vs. chronic ethanol intoxication and show thesignificant differences between these two states on patient management.
- Megadoses of antioxidants are a great way to catch up on deficiencies, and since they are natural, they have no harmful side effects. true or falseall of the following are correct regarding propyl thiouracil, EXCEPT a) it blocks peripheral deiodination b) it can be used for treating hyperthyroidismpregnancy and nursing mother c) its clinical effects are observed immediately following administration d) it is safe to be used for hepatic failure patientCalculate KI' of the inhibitor from the information given. All information may not be needed to calculate. K'm = (29Ki+1.45x10^-10)/Ki Vmax = 11.7 µMs-1 Kcat = 130 s^-1 Vo = 3.0 μMs-1 S = 10 μM Et = 0.09 µM Inhibitor Concentration = 5x10^-12
- We can suspect hypoglycaemia after use of:A. SulfonamidesB. CoffeinumC. Cardiac glycosidesD. PenicillinE. Levothyroxinevitamin e is a proven antioxidant and may help in fighting cancer and heart disease is the statement reasonable why or why not?a. What are the advantages of the glucose peroxidase method of determining blood sugar? b. The principle of spectrophotometer is is based on _____ law. c. Differenciate hyperglycemia from hypoglycemia.
- Discuss the biochemical effects of acute vs. chronic ethanol intoxication and show the significant differences between these two states on patient management. Explain how consumption of ethanol can lead to hyperuricaemia and gout in high-risk patientsWhat do you think about the possibility that NAD treatment could ease the signs of a hangover? Explain?All of the following qualities apply to nateglinide, except:A. Short half-lifeB. Minimal risk for developing hypoglycemiaC. Metabolized by liver D. Restores early insulin secretionE. Excreted by kidneys