I Case Study 3 2.5% Hydrocortisone in Glaxal Base You receive the following prescription from a regular female patient: 2.5% HC in Glaxal Sig: Apply bid for 5 days then prn Mitte: 30 grams As this strength of hydrocortisone cream is not available commercially, your pharmacy regul. compounds it and so has hydrocortisone powder in stock. Questions Calculate the amount of each ingredient required and complete a batch sheet. Describe geometric dilution. Prepare a product label, including expiry date. What is a possible therapeutic indication for this product?
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- Using conversion factors, solve each of the following clinicalproblems:a. A nurse practitioner prepares an injection of promethazine,an antihistamine used to treat allergic rhinitis. If thestock bottle is labeled 25 mg /mL and the order is a doseof 12.5 mg, how many milliliters will the nurse draw up inthe syringe?b. You are to give ampicillin 25 mg/kg to a child with a massof 62 lb. If stock on hand is 250 mg /capsule, how manycapsules should be given?Calculate KI' of the inhibitor from the information given. All information may not be needed to calculate. K'm = (29Ki+1.45x10^-10)/Ki Vmax = 11.7 µMs-1 Kcat = 130 s^-1 Vo = 3.0 μMs-1 S = 10 μM Et = 0.09 µM Inhibitor Concentration = 5x10^-12Q.1. A solution consists of 40% by mass of a trimer with M = 25 kgmol-1 and its monomer. What average molar mass would be obtained from measurement of (a) osmotic pressure (b) light scattering?
- Drug Calculations. Solve all the questions(28)The bioavailability of drug X after oral administration is 38%. Which of the following best explains this level of systematic bioavailability?? (A) Adipose distribution. (B) Hepatic Metabolism. (C) Plasma Protein Binding. (D) Pulmonary Metabolism. (E) Renal Metabolism(Formulation using Pearson Square Method) Using Pearson Square Method, formulate 50 kilograms of a ration with 18% CP using soybean meal and yellow corn. How much of each ingredient (in kg) should be used in order to satisfy the protein requirement of the animal?
- How was thermal stability measured in this paper and describe how GRL-1720 and 5h affect the thermal stability of Mpro and which drug has the larger effect? https://www.nature.com/articles/s41467-021-20900-622. A child weighing 59 lb and 48 inches tall is receiving an anti-inflammatory agent at a regimen of 60 mg/m2 PO BID. What volume, in milliliters, of the commercially available 50 mg/tsp suspension will the patient receive per dose? Round to the nearest tenths placeDosage Calculations27. A baby weighs 3.2 kg. The dose calls for 0.4 mg/kg. What is the dosage? Drug Calculations28. How much active ingredient in 20 cc of a 15% solution? 29. You have 1:1000 concentration of epinephrine. How many mLs do you need to draw up if you want togive 45 mg of the drug? 30. How many mg of an active ingredient are in 4 mL of a 0.4% solution? 31. How many mLs do you need to give to get 20 mg of a 350mg/20mL dose? 32. Albuterol syrup is available in 2mg/5 mL. How much do you take if 6 mg is ordered? 33. Promazine HCL comes as 500 mg/10 mL. How many milliliters are needed to give a 150 mg dose? 34. 4 mg of morphine sulfate is ordered. you have a vial with 10mg/mL. How many mLs do you need todeliver? 35. Albuterol syrup is available in a 2 mg/ 5 mL concentration. If a dose schedule of 0.1 mg/kg is used, howmuch syrup is needed for a 30 kg. child? 36. A pediatric dose of oxytetracycline of 100 mg is ordered. The dosage form is an oral suspensioncontaining 125 mg/5cc.…
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