Give the reason for adding cyclohexane in the flow chart.

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter8: Forms Of Drugs And How They Act
Section: Chapter Questions
Problem 30RQ
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Give the reason for adding cyclohexane in the flow chart.
Add an excess of methanol to 8.0g of
benzoic acid followed by a few drops
of concentrated sulfuric acid.
Cool the mixture, pour into a
separating funnel and add a similar
volume of cyclohexane.
Wash the cyclohexane layer left in the
separating funnel with sodium
carbonate solution.
Vigorously shake the mixture, allow to
settle. Run off the lower layer.
Run off the cyclohexane layer into a
conical flask and allow to stand over
solid anhydrous sodium sulfate and
then filter.
Distil the cyclohexane layer collecting
the distillate above 190 °C.
8/16
Transcribed Image Text:Add an excess of methanol to 8.0g of benzoic acid followed by a few drops of concentrated sulfuric acid. Cool the mixture, pour into a separating funnel and add a similar volume of cyclohexane. Wash the cyclohexane layer left in the separating funnel with sodium carbonate solution. Vigorously shake the mixture, allow to settle. Run off the lower layer. Run off the cyclohexane layer into a conical flask and allow to stand over solid anhydrous sodium sulfate and then filter. Distil the cyclohexane layer collecting the distillate above 190 °C. 8/16
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