Although the first two carbons of fructose and glucose are identical in structure to DHAP and GADP (from glycolysis), DHAP and GADP equilibriate on their in solution to favor the ketone over the aldehyde, while fructose and glucose do not.  Why? a)The larger size of the molecule sterically hinders the isomerization b)The larger sugars have more OH groups which hydrogen bond and disrupt isomerization c)The larger sugars cyclize, and there is no carbonyl to isomerize in the cyclic form d)The larger sugars cyclize, and in the cyclic form the hydrogen bonding is very strong e)The larger sugars are less soluble in water than the smaller sugars

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter3: The Chemistry Of Life: Organic Compounds
Section: Chapter Questions
Problem 4TYU: The synthetic process by which monomers are covalently linked is (a) hydrolysis (b) isomerization...
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Although the first two carbons of fructose and glucose are identical in structure to DHAP and GADP (from glycolysis), DHAP and GADP equilibriate on their in solution to favor the ketone over the aldehyde, while fructose and glucose do not.  Why?

a)The larger size of the molecule sterically hinders the isomerization
b)The larger sugars have more OH groups which hydrogen bond and disrupt isomerization
c)The larger sugars cyclize, and there is no carbonyl to isomerize in the cyclic form
d)The larger sugars cyclize, and in the cyclic form the hydrogen bonding is very strong
e)The larger sugars are less soluble in water than the smaller sugars
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