Animal Models Your friend told you that he tested a candidate drug against Covid-19, and his results show that his lab mice (Mus musculus), when given SARS-CoV-2 + the "drug X", showed promising results. Using the table below, what can you tell him? What recommendations can you make? Note: A dot means it is identical to that of human (Homo sapiens).
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- 1. Search for the `P06858` a) Give information about the PTM and Processing of this protein. b) Which position has maximum amount of variations? Give details about the variations. (Eg: What kind of variation? Feature ID? Disease association? etc..)4. A physician orders an IV drip containing 12 million units per day of penicillin G potassium for a patient with otitis media (middle ear infection). A. If 18.2 mL of diluent is used to reconstitute the penicillin G, how many mL should be injected? B. If 8.2 mL of diluent is used to reconstitute the penicillin G, how many mL should be injected? C. If 3.2 mL of diluent is used to reconstitute the penicillin G, how many mL should be injected?1. In bacteria, Which of the following mechanisms is the least probable in promoting antibiotic resistance? A. receive a gene or genes that code for capsule production B. receive a gene or genes that code for a “multidrug resistant” bomb C. a chromosomal mutation that alters membrane permeability D. a chromosomal mutation that alters the shape of the drug receptor E. receiving a gene that codes for an enzyme that destroys a particular antibiotic 2. Why are Pseudomonas aeruginosa infections difficult to treat? A. Because they form biofilms, which are difficult for antibiotics to penetrate. B. Because they have a special endotoxin that degrades many antibiotics. C. Because we do not have any antibiotics that target P. aeruginosa. D. Because they are gram-positive bacteria, which are harder to treat. 3. Which of the following drugs is not used primarily to treat tuberculosis A. ethambutol B. rifampin C. isoniazid D. sulfonamide
- 5. Which statement regarding the use of rocuronium is true? Don't copy A) It has more rapid onset than vecuronium B) It has the same mechanism of action as succinylcholine C) It is the least cardiac stable neuromuscular blocking agent D) It has a significantly longer duration than vecuronium?Dr Janis toboggan has two patients who were admitted to her hospital with covid-19. And she gave them both the drug known as remdesivir. Patient A got better and was released from the hospital in two days, but it took a week for patient b to recover and be sent home. That’s interesting though dr toboggan. “Why did the drug work differently in the two patients? Remedesivir seemed to help one patient but not the other. Maybe the drug speeds up recovery but the patients had different levels of infection. Or, maybe remdesvir didn’t have any effect on recovery, and the patients were just at a different places in their infections by the Novel corona virus. To find which hypothesis was a better explanation her data, Dr To boggan applies a little deductive reading. “What if I set up a situation where I have two patients at the same point in their infection and I give one the drug and one not? If remedesivir speeds up recovery, then the one with the drug will recover faster. But if…1. What are the reasons why the products based on onion and garlic that use against COVID-19 can be placed in the market? Explain and discuss it thoroughly. I need a comprehensive answer.
- Covid-19 is one of the current problems that the world is experiencing. It is an infectious disease caused by severe acute respiratory syndrome which affects different people in different ways. How do you think Biology can be used to solve this problem? (Include also how life may be valued.)1. In chipmunks, the relationship between genotype and the age at which heart attacks occur is similar to that in squirrels. However, in chipmunks that are homozygous for the normal LDL receptor allele, Fn, only normal receptors are present. Heterozygous chipmunks have a single type of LDL receptor present on the cell surface, but those defective receptors exhibit only 50% of the normal LDL binding capacity. Finally, chipmunks that are homozygous for the defective receptor allele possess receptors with virtually no LDL binding ability. NAME and DEFINE the genetic phenomenon illustrated here.2. Bacteriophage are very specific in the types of cells they can infect. Some see this as a possible therapy to help treat against bacterial infections. Please discuss pros and cons of this type of therapy with proper support.
- All of the following are true of integrins except (a) they are receptor proteins (b) they help organize the cytoskeleton (c) they are part of the ECM (d) they are important in cell signaling (e) they are located in the plasma membrane1. One type of vertebrate cell that is thought to lack integrins is the erythrocyte (red blood cell).Does this surprise you? Why or why not? 2. How are integrins able to link the cell surface with materials that make up the ECM? How do the inactive and active structures of integrins differ from one another structurally and functionally? What is the significance of the presence of an RGD motif in an integrin ligand?4. Explain the RAAS mechanism.,!