Answer the following questions about the biosynthesis of the natural product JHIII, starting from the intermediate structure 5. steps 32₂2₂ COOMe OPP JHIII (a) Draw a biosynthetic scheme, using the following biosynthetic intermediates 6-9, to account for the formation of JHIII from the structure 5. Pay particular attention to the order of the steps. COOH COOH OH (b) From the list below, assign an enzyme or enzyme/co-factor combination to each step of the scheme drawn in part (a).

Answer the following questions about the biosynthesis of the natural product JHIII, starting from the intermediate structure 5. steps 32₂2₂ COOMe OPP JHIII (a) Draw a biosynthetic scheme, using the following biosynthetic intermediates 6-9, to account for the formation of JHIII from the structure 5. Pay particular attention to the order of the steps. COOH COOH OH (b) From the list below, assign an enzyme or enzyme/co-factor combination to each step of the scheme drawn in part (a).

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter24: Catalytic Carbon-carbon Bond Formation

Section: Chapter Questions

Problem 24.36P

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