Arrange the following steps in fatty acids degradation in the correct order : A. beta-oxidation of acyl COA B. Fatty acid conjugated to coenzyme A C. Citric acid (Krebs) cycle D. Fatty acid carried by albumin E. Production of Acetyl CoA, NADH, and FADH₂ F. Acyl carnitine transported across the inner mitochondrial membrane
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- Before a fatty acid can undergo β-oxidation, it must be activated and then shuttled across the inner mitochondrial membrane. The activating agent and shuttle molecule are, respectively: A. CoA and carnitine B. CoA and citrate C. acetyl CoA and carnitine D. acetyl CoA and citratePlace the following list of reactions or relevant locations in the β oxidation of fatty acids in the proper order. (a) Reaction with carnitine (b) Fatty acid in the cytoplasm (c) Activation of fatty acid by joining to CoA (d) Hydration (e) NAD+ -linked oxidation (f) Thiolysis (g) Acyl CoA in mitochondrion (h) FAD-linked oxidation.How many molecules of acetyl-CoA are produced by catabolism of the following fatty acids, and how many b oxidations are needed?(a) Palmitic acid, CH3(CH2)14COOH(b) Lignoceric acid, CH3(CH2)22COOH
- In the context of fatty acid oxidation to acetyl CoA, indicate whether each of the following substances is involved in (1) fatty acid activation, (2) fatty acid trans-port, or (3) b-oxidation pathway. More than one choice may be correct in a given situation. a. AMp b. FAD c. Acyl CoA d. H2OWhich of the following is the correct account for acetyl CoA, NADH , and FADH2 for the beta-oxidation of stearic acid (saturated fatty acid with 18 carbon atoms)? -9;8;5 -9;8;8 -18;9;9 -18;18;18 -9;9;9Which of the following statements is/are TRUE about fatty acid activation before β-oxidation? I. The process consumes energy equivalent to two moles of ATP. II. The fatty acid is activated by ATP to give a fatty acyl-CoA.
- Which of the following statements about the "central role" of TCA is/are correct? a. Some metabolic intermediates of TCA are used as non-carbohydrate sources for gluconeogenesis. b. β-oxidation of lipids produces acetyl-CoA that can enter TCA. c. All metabolic intermediates in TCA are used in the biosynthesis of amino acids. d. Degraded amino acids are converted to metabolic intermediates of TCA, then to ketone bodies.All of the following classes of enzymes catalyze the Fatty acid synthesis except a. synthetase b. Synthase c. Carboxylase d. DehydrgenWhich of the following statements is TRUE about fatty acid biosynthesis? Group of answer choices: NADH is used as the reducing equivalent in the process. Malonyl ACP is the donor of the acetyl group. The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons. Oxaloacetate carries acetyl CoA to the cytosol.
- Assume that the following fatty acid is synthesized from acetyl-CoA in the cytosol by fatty acidsynthase. Which of the following statements is true? The last two carbon atoms that are added to the fatty acid are carbon atoms #15 and #16 Synthesis of the fatty acid needs 8 molecules of NADPH + H+ Both A and B Neither A nor BComplete the table below. Consider docosanoic acid (C21H43CO2H) Questions Solutions Answers a. Label the alpha and beta carbons. b. Draw the acetyl CoA derived from this fatty acid. c. How many acetyl CoA molecules are formed by complete B-oxidation? d. How many cycles of B-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid?Which of the following metabolite negatively regulates pyruvate kinase? Select one: a. Fructose-1,6-Bisphosphate b. Acetyl CoA C. Alanine d. Citrate