Assume that we want to minimize a function using evolutionary algorithm. For our coding process, we adopt a population of 6 chromosomes namely c1, c2, c3, c4, c5, and c6 where their corresponding fitness values are 5, 10, 11, 2, 7, and 17 respectively. For the next generation using the roulette wheel selection, the probability of selecting these chromosomes as one of the parent chromosomes, for chromosome c1 is for chromosome c2 is , for chromosome c3 is for chromosome c4 is for chromosome c5 is and for chromosome c6 is
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- Consider two loci A and B that are 30 cM apart on chromosome 1 in the fruit fly. A paracentric inversion is found to span about half of the distance between these loci, but not include either A or B. What is the approximate recombination frequency expected for these loci in … flies that are heterozygous for this inversion? RF(A-B) for heterozygous flies is … flies that are homozygous for this inversion? RF(A-B) for homozygous flies is …Consider the following "pericentric" ("around the center") inversion. In one an individual, a simplified 8-gene sequence along one chromosome is 1234 5678 while a pericentric inversion occurred on their other homologous chromosome, resulting in the sequence 1265 4378 (the dot represents the centromere). Draw these homologous chromosomes lined up (as during crossing over, in Prophase l). If a crossover event occurred between gene locus 3 and 4 (slicing between them) on the original chromosome, what would the crossover products look like? What would be the "problem" with each of the chromosomes that result?Malaria is a leading cause of human illness and mortality worldwide, with 200 million people infected and 600,000 deaths each year. In the 1960s, the incidence of malaria was reduced owing to the use of insecticides that killed mosquitoes in the genus Anopheles, which transmit the disease from person to person. But today, mosquitoes are becoming resistant to insecticides--causing a resurgence in malaria. In this exercise, you will investigate whether alleles encoding resistance to insecticides have been transferred between closely related species of Anopheles. To find out whether transfers have occurred, you will analyze DNA results from two species of mosquitoes that transmit malaria (Anopheles gambiae and A. coluzzii) and from A. gambiae × A. coluzzii hybrids. Resistance to DDT and other insecticides in Anopheles is affected by a sodium channel gene, kdr. The allele r of this gene confers resistance, while the wild type (+/+) genotype is not resistant. Researchers sequenced the kdr…
- Construct a map of the chromosome, with the most accurate map distances, from the following recombination frequencies between individual pairs of genes: C –F 13%, V –F 20%, V –C 8%, S –F 4%, C –S 9%,One particularly useful feature of the Hardy-Weinberg equation is that it allows us to estimate the frequency of heterozygotes for recessive genetic diseases, assuming that Hardy-Weinberg equilibrium exists. As an example, let’s consider cystic fibrosis, which is a human genetic disease involving a gene that encodes a chloride transporter. Persons with this disorder have an irregularity in salt and water balance. One of the symptoms is thick mucus in the lungs that can contribute to repeated lung infections. In populations of Northern European descent, the frequency of affected individuals is approximately 1 in 2500. Because this is a recessive disorder, affected individuals are homozygotes. Assuming that the population is in Hardy-Weinberg equilibrium, what is the frequency of individuals who are heterozygous carriers?During the resolution of polyploidy, the subgenomes must function as a single unit. This often results in at least partial dominance of one subgenome over the other. Sequencing of polyploid genomes has demonstrated that TE density is often negatively associated with dominance. If you were presented with data suggesting that a subgenome with higher TE density associated with gene space was dominant, how could you explain the results? Describe al follow up experiment.
- Recombination frequencies between four genetically-linked loci in corn are shown in the following table: Loci Recombination Frequency (%) L and Q 20 Q and R 50 R and L 30 Q and W 13 L and W 7 What is the order of the genes on the chromosome? (note: The same answer can be represented forward or backwards. e.g. A B C D = D C B A) LQWR RQWL LRQW QRLW RLWQAccording to the endosymbiosis theory, mitochondria and chloroplasts are derived from bacteria that took up residence withineukaryotic cells. At one time, prior to being taken up by eukaryoticcells, these bacteria were free-living organisms. However, we cannot take a mitochondrion or chloroplast out of a living eukaryoticcell and get it to survive and replicate on its own. Discuss why not.Consider the genetic map below. (a) In a total of 1000 observed progeny, how many would be expected to be parental, non-recombinant? (b) If the total number of observed double-crossover recombinant progeny is 0, what is the interference? Show step by step A-------10cm-----B—2.5cm----C
- For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene? Lets say that at age 45 the third granddaughter III-3, is diagnosed with breast cancer. Now recalculate the recombination rate between the marker locus D17S74 and the breast cancer gene? Use only the 5 women in your analysis:the two daugthers in generation II and the three granddaughters in generation IINeurospora of genotype a + c are crossed withNeurospora of genotype + b +. (Here, + is shorthandfor the wild-type allele.) The following tetrads areobtained (note that the genotype of the four sporepairs in an ascus are listed, rather than listing alleight spores):a + c a b c + + c + b c a b + a + ca + c a b c a + c a b c a b + a b c+ b + + + + + b + + + + + + c + + ++ b + + + + a b + a + + + + c + b +137 141 26 25 2 3a. In how many cells has meiosis occurred to yieldthese data?b. Give the best genetic map to explain these results.Indicate all relevant genetic distances, both betweengenes and between each gene and the centromere.c. Diagram a meiosis that could give rise to oneof the three tetrads in the class at the far right inthe list. The numbers of chromosomes in the somatic cells ofseveral oat varieties (Avena species) are: sand oats(Avena strigosa)—14; slender wild oats (Avenabarata)—28; and cultivated oats (Avena sativa)—42.a. What is the basic chromosome number (x) in Avena?b. What is the ploidy for each of the different species?c. What is the number of chromosomes in the gametesproduced by each of these oat varieties?d. What is the n number of chromosomes in eachspecies?