Can you help find the charge for the c terminal? At pH 1, the charge on the C-terminal carboxyl group is+1-1O O O Peptide lonizationConsider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln.You will be asked to state the charge on the functional groups of thispeptide at pH 1 and pH 9.5.You will also be asked to calculate the net charge on the peptide. You mayfind it convenient to write down the charge on each group on a piece ofpaper as you go along, so that you can add them up at the end.Assume the following generic pK, values for ionizable functional groups:a-carboxyl:side-chain carboxyl:imidazole:3.14.16.0a-amino:8.0thiol:8.3E-amino:10.8aromatic hydroxyl:guanidino:10.912.5

Answered: At pH 1, the charge on the C-terminal…

Science

Biochemistry

At pH 1, the charge on the C-terminal carboxyl group is

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter3: Biological Macromolecules

Section: Chapter Questions

Problem 23CTQ: Amino acids have the generic structure seen below, where R represents different carbon-based side...

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Question

Can you help find the charge for the c terminal?

At pH 1, the charge on the C-terminal carboxyl group is
+1
-1
O O O

Peptide lonization
Consider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln.
You will be asked to state the charge on the functional groups of this
peptide at pH 1 and pH 9.5.
You will also be asked to calculate the net charge on the peptide. You may
find it convenient to write down the charge on each group on a piece of
paper as you go along, so that you can add them up at the end.
Assume the following generic pK, values for ionizable functional groups:
a-carboxyl:
side-chain carboxyl:
imidazole:
3.1
4.1
6.0
a-amino:
8.0
thiol:
8.3
E-amino:
10.8
aromatic hydroxyl:
guanidino:
10.9
12.5

Expert Solution

Step 1

Peptide bond: When two amino acids are joined together releasing a water molecule and forming alpha nitrogen of one amino acid and carbonyl carbon is known as a peptide bond.

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