As a research project, a group of students created a pedigreeshowing the incidence of sickle cell anemia in a family overthree generations.Generation I12Generation II47Generation III8 91011Unaffected maleUnaffected femaleAffected maleAffected female Based on the pedigree, drag a claim about the inheritancepattern of sickle cell anemia into the appropriate box. Drag anevidence statement into the appropriate box to justify theclaim.ClaimEvidence!::Claim 1-Sickle cell anemia is inherited in anautosomal recessive pattern.::Claim 2-Sickle cell anemia is inherited in anautosomal dominant pattern.Evidence 1-Individual 11 has sickle cell anemia, buther parents do not.::Evidence 2-Individuals 8 and 9 have sickle cellanemia, and their father, individual 3, is also affected.::Evidence 3-Individual 1 has sickle cell anemia, buthis children do not.

Answered: Based on the pedigree, drag a claim…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 5QP: Achondroplasia is a rare dominant autosomal defect resulting in dwarfism. The unaffected brother of...

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Question

As a research project, a group of students created a pedigree
showing the incidence of sickle cell anemia in a family over
three generations.
Generation I
1
2
Generation II
4
7
Generation III
8 9
10
11
Unaffected male
Unaffected female
Affected male
Affected female

Based on the pedigree, drag a claim about the inheritance
pattern of sickle cell anemia into the appropriate box. Drag an
evidence statement into the appropriate box to justify the
claim.
Claim
Evidence!
::
Claim 1-Sickle cell anemia is inherited in an
autosomal recessive pattern.
::
Claim 2-Sickle cell anemia is inherited in an
autosomal dominant pattern.
Evidence 1-Individual 11 has sickle cell anemia, but
her parents do not.
::
Evidence 2-Individuals 8 and 9 have sickle cell
anemia, and their father, individual 3, is also affected.
::
Evidence 3-Individual 1 has sickle cell anemia, but
his children do not.

Expert Solution

Introduction

Sickle cell anemia : in this disease the RBCs become sickle shaped, due to which the WBCs attack on them and phagocytose them resulting in decrease in blood RBC count and causes anemia.

This disease is an Autosomal recessive disease. The disease is controlled by a single pair of allele Hb^Aand Hb^S, the gene Hb^Sis defective while Hb^Ais normal gene.

The organisms with homozygous defective form of gene i.e. Hb^SHb^Sare infected with the disease.

While those who are heterozygous for the gene will be carrier of the disease, and such parents can transfer this disease to their offspring even when they themselves are not affected.

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