Beta lactam antibiotics disrupt peptidoglycan synthesis by binding to the bacterial enzyme necessary for peptide bond formation between TPCS of different PG layers.
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Introduction:
The antibiotics that contain a lactam ring in their atomic design are alluded to as lactam antibiotics.
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- Describe the features of a riboswitch that is activated byexcess metabolite concentrations.Beta-lactam antibiotics work by? O A. cleaving peptide side chains O B. preventing cross-linking of the peptide side chains by transpeptidase O C. cleaving the 1,4 beta-glycosidic bond between the NAM and NAG © D. inhibiting the action of bactoprenol O E. preventing peptidoglycan from being flipped to the external side of the plasma membraneExplain the sequence of molecular events that leadsto the synthesis of (p)ppGpp in Escherichia coli duringthe stringent response.
- Linezolid is a new type of antibiotic that inhibits protein synthesis in several bacterial species by bindingto the 50S subunit of the ribosome and inhibiting its ability to participate in the formation of translationalinitiation complexes. Physicians are particularlyinterested in this antibiotic for treating pneumoniacaused by penicillin-resistant Streptococcus pneumoniae (also called pneumococci). To explore themechanisms by which pneumococci can developresistance to linezolid, you first want to identifylinezolid-resistant strains. Next, using one of thesestrains as starting material, you want to identifyderivatives of these mutants that are no longertolerant of linezolid.a. Outline the techniques you would use to identifylinezolid-resistant mutant pneumococci andlinezolid-sensitive derivatives of these mutants.In each case, would your techniques involve directselection, screening, replica plating, treating withmutagens, or testing for a visible phenotype?b. Suggest possible…The anitbiotic penicillin is effective against bacteria by _____. inhibiting the sunthesis of peptidoglycan blockimng the adhesion of the capsule to the substrate inhibiting the formation of fimbriae blocking the operation of the proton pump Interfering with conjugationEach species of bacteria has its own distinctive cell surface. Thecharacteristics of the cell surface play an important role in processessuch as conjugation and transduction. For example, certainstrains of E. coli have pili on their cell surface. These pili enableE. coli to conjugate with other E. coli and also enable certain bacteriophages (such as M13) to bind to the surface of the E. coli andgain entry into the cytoplasm. With these ideas in mind, explainwhich forms of genetic transfer (i.e., conjugation, transduction,and transformation) are more likely to occur between different speciesof bacteria. Discuss some of the potential consequences ofinterspecies genetic transfer.
- Lysozyme cleaves the bacterial cell wall at ___________. the site between NAM and NAG NAG NAM lipoteichoic acidDiscuss the virulence of bacterial pathogens on the basis of proteinase activity.There have been recurring cases of mad-cow disease in the United Kingdom since the mid-1990s. Mad-cow disease is caused by a prion, an infectious particle that consists only of protein. In 1986, the media began reporting that cows all over England were dying from a mysterious disease. Initially, there was little interest in determining whether humans could be affected. For 10 years, the British government maintained that this unusual disease could not be transmitted to humans. However, in March 1996, the government did an about-face and announced that bovine spongiform encephalopathy (BSE), commonly known as mad-cow disease, can be transmitted to humans, where it is known as variant Creutzfeldt-Jakob disease (VCJD). As in cows, this disease eats away at the nervous system, destroying the brain and essentially turning it into a spongelike structure filled with holes. Victims experience dementia; confusion; loss of speech, sight, and hearing; convulsions; coma; and finally death. Prion diseases are always fatal, and there is no treatment. Precautionary measures taken in Britain to prevent this disease in humans may have begun too late. Many of the victims contracted it over a decade earlier, when the BSE epidemic began, and the incubation period is long (VCJD has an incubation period of 10 to 40 years). A recent study concluded that 1 in 2,000 people in Great Britain carry the abnormally folded protein that causes VCJD. In spite of these numbers, the death rate from VCJD remains low. It is not clear whether this means that the incubation period for the disease is much longer than previously thought, or whether they may never develop the disease. How can a prion replicate itself without genetic material?
- A cell infected with lambda bacteriophage can follow one of two pathways: the lytic or lysogenic pathway. Describe the similarities and differences between the structure of cI and Cro, paying particular attention to the features that allow them to carry out their different functions.a. Using table as a reference, find and explain the differencesbetween the results for Staphylococcus and Pseudomonas. Are anyof these drugs broad spectrum?b. Explain the difference in the MIC of E. coli for penicillin versusampicillin.The peptidoglycan in bacterial cell walls is built in part by penicillin-binding proteins. (PBPs). What is the normal function of these PBPs?