Bill is color blind and has developed Huntington’s disease. His mother has normal vision and does not have Huntington’s disease. Susan does not have Huntington’s disease and has normal vision. Her mother is normal in all respects, but her father is color blind and suffers from Huntington’s disease. Bill's father is not color blind or have huntington's disease. a. Make a pedigree and indicate the alleles for each individuals traits. b. If Bill and Susan marry, and ignoring the fact that Huntington’s disease is lethal, what types and proportions of children can they produce? c. If Bill and Susan marry, what is the probability that the first two children will be color blind females without HD, the third child will be a color blind male with Huntington.

Bill is color blind and has developed Huntington’s disease. His mother has normal vision and does not have Huntington’s disease. Susan does not have Huntington’s disease and has normal vision. Her mother is normal in all respects, but her father is color blind and suffers from Huntington’s disease. Bill's father is not color blind or have huntington's disease. a. Make a pedigree and indicate the alleles for each individuals traits. b. If Bill and Susan marry, and ignoring the fact that Huntington’s disease is lethal, what types and proportions of children can they produce? c. If Bill and Susan marry, what is the probability that the first two children will be color blind females without HD, the third child will be a color blind male with Huntington.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter18: Genetics Of Behavior

Section: Chapter Questions

Problem 14QP: A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known...

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What are the genotypes of the mother and father in the pedigree below? The pedigree shows albinism (an autosomal recessive trait). The shaded shapes represent albino individuals. a. mother - homozygous dominant; father - homozygous dominant b. mother - heterozygous; father - homozygous recessive c. mother - homozygous recessive; father - heterozygous d. mother - heterozygous; father - heterozygous e. mother - homozygous dominant; father - homozygous recessive
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?
A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?
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You have been hired to produce a family tree for three generations of a family where a disorder called “blinky” syndrome is observed. People who suffer from blinky syndrome blink their eyes rapidly when they look at bright lights. In order to draw a pedigree chart for this family, you interview Mike and Annie. Neither suffer from this syndrome. Annie’s mother is normal, while Annie’s father blinked like crazy at bright lights. Annie has one sister and one brother and both of them are unaffected. While Annie’s sister has yet to have kids, her brother married a blinky sufferer. Mike’s mother is a blinker while his father is normal. Mike’s brother is just like their mother. In addition, this brother married a blinker. Mike’s sister is normal - as is her husband and their one boy. Draw a pedigree chart below in order to answer the following on the next page. Use the letters A and a for the genotypes. If more than one genotype is possible for an individual - you may write it as A with a…
If Mendel chose to study inheritance of height in human, would he have likely discovered the same princeple of heredity that he discovered in working with pea plants? A. Yes, because human height is a continuously varying trait, just like the traits Mendel studied in pea plants. B. No, because the generation time in humans is relatively long compared with pea plants. C. Yes, because the principles of segregation and independent assortment also apply to human genes. D. No, because human height is not genetically determined.
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