Br COзн Et,N DBU CH;SO2 phenylacetic acid CH;SO2 х rofecoxib

Q: Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone; but…

A: SOLUTION: Step 1: The organic reaction in which a chemical compound containing a carbonyl group acts…

Q: Rank the labeled N atoms in the anticancer drug imatinib (trade name Gleevec) in order of increasing…

A: According to Lewis acid-base theory, the acidic and basic nature of the substance. A Lewis base can…

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A:

Q: Aspirin is an anti-inflammatory agent because it inhibits the conversion of arachidonic acid to…

A:

Q: Answer the following questions about benzphetamine, a habit-forming diet pill sold under the trade…

A: (a)

Q: Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid  D. C is a key…

A:

Q: Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid D. C is a key…

A: A stepwise mechanism for the conversion of lactone C to carboxylic acid D can be drawn as

Q: Benzylamine synthesis from benzaldehyde follows the mechanism of reductive amination BECAUSE…

A: Statement 1: Benzylamine synthesis from benzaldehyde follows the mechanism of reductive amination…

Q: (a) Explain how NaBH4 in CH3OH can reduce hemiacetal A to butane-1,4-diol (HOCH2CH2CH2CH2OH). (b)…

A: The reaction of hemiacetal A will be given by the sodium borohydride in presence of methanol as-

Q: What products are formed by hydrolysis of each imine or enamine?

A: The products are formed by hydrolysis of each imine or enamine has to be determined.

Q: Devise a synthesis of each compound from the given starting material(s). Albuterol is a…

A: a. Synthesis of albuterol is given below, The first step involves the Friedel Crafts acylation…

Q: Although codeine occurs in low concentration in the opium poppy, most of the codeine used in…

A:

Q: Nabumetone is a pain reliever and anti-inammatory agent sold under the brand name of Relafen.a.…

A: a.

Q: (a) Explain how NaBH4 in CH3OH can reduce hemiacetal A to butane-1,4-diol (HOCH2CH2CH2CH2OH). (b)…

A: (a) The given compound A is a hemiacetal. Sodium borohydride (NaBH4) is a strong reducing agent. It…

Q: The following intermediate was needed for the synthesis of tamoxifen, a widely used antiestrogen…

A:

Q: Draw the structure (including stereochemistry) of the cyclic hemiacetal(s) formed when each hydroxy…

A: Concept introduction: Hemiacetal are formed for the compound having both hydroxyl group and aldehyde…

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A: In the given reaction, the base abstracts the acidic proton from carboxylic acid. The phenyl acetate…

Q: In the 1880's, Acetanilide, sold under the name Antifebrin, was widely used as a pain reliever and…

A: Here we have to write the mechanism of acid catalyzed hydrolysis of acetanilide and synthesis of…

Q: Answer the following questions about atomoxetine, a drug used to treatattention deficit…

A: The amides that can be reduced to form atomoxetine are:  1. 2.

Q: What enolate is formed when each ketone is treated with LDA in THF solution? What enolate is formed…

A: When a ketone is treated with LDA in presence of THF solution to form an enolate ion. The strong…

Q: n-acetylazoles go through hydrolysis more than regular amides. propose a reason for the reactivity…

A: Amide hydrolysis is not so easy because of the donating ability of lone pair of electrons on…

Q: Quinapril (trade name Accupril) is used to treat high blood pressure and congestive heart failure.…

A:

Q: Etoposide, sold as a phosphate derivative with the trade name of Etopophos, is used for the…

A: (a) Acetals are groups in which C atom is bonded with 2 O atoms through single bonds. They are used…

Q: Devise a synthesis of each compound from the given starting material(s). Albuterol is a…

A: Given that,

Q: Identify A in the following reaction sequence, and draw a mechanism for the conversion of A to B. B…

A: In Sharpless epoxidation, the epoxidation of the double bond will take place. Note:- Direction…

Q: During the metabolism of glucose, glyceraldehyde 3-phosphate is converted to dihydroxyacetone…

A: Keto –enol tautomerizations means the chemical equilibrium between enol form and keto form. Keto…

Q: What enolate is formed when each ketone is treated with LDA in THF solution? What enolate is formed…

A: LDA is a strong non nucleophilic base and it abstracts proton from alpha position of less hindered…

Q: What alkyl halides are needed to prepare each ketone using the acetoacetic ester synthesis?

A:

Q: Treatment of ethyl acetoacetate with NaOEt (2 equiv) and BrCH2CH2Br forms compound X. This reaction…

A: Sodium ethoxide (NaOEt) reagent mainly behaves as "nucleophile". It abstracts hydrogen that is…

Q: Which of the following reactions represents the synthesis of dibenzalacetone? Ph = phenyl

A: All the reactions given are same and we only need to check which one is the balanced chemical…

Q: Draw a stepwise mechanism for the following reaction, one step in thesynthesis of the…

A: A stepwise mechanism for the following reaction, one step in the synthesis of the…

Q: Explain why imidazolides are much more reactive than other amides in nucleophilic acyl substitution.

A: It is known that, imidazolides are much more reactive than other amides in nucleophilic acyl…

Q: Which of the following is the most active acyl compound in terms of susceptibility to react? A.…

A: The question is based on the concept of organic reactions. We have  to identify which of the given…

Q: Which of the following is the most active acyl compound in terms of susceptibility to react? A.…

A: The chlorine atom is larger in size than the carbon atom, hence it decreases the electron density…

Q: What products are formed by hydrolysis of attached imine or enamine?

A: The hydrolysis of imine gives the corresponding aldehyde or ketone. The reaction proceeds in the…

Q: What Grignard reagent and carbonyl compound can be used to prepare the antidepressant venlafaxine…

A: The crabonyl compound and the grignard reagent that can be used to form venlafaxine is as follows:…

Q: Draw a stepwise mechanism for the following imine hydrolysis.

A: The hydrolysis of imine leads to the formation of corresponding amine and a carbonyl-containing…

Q: From each pair of compounds, choose the one with the indicated property and explain your choice. a)…

A:

Q: Reductive amination requires a hydrogen on the carbonyl carbon to proceed BECAUSE Reductive…

A: Reductive amination reaction is a “carbonyl condensation reaction” is one in which two carbonyl‑…

Q: Treatment of ethyl acetoacetate with NaOEt (2 equiv) and BrCH2CH2Br forms compound X. This reaction…

A: The structure of "X" in the formation of illudin-S by acetoacetic ester synthesis is shown below.

Q: Draw and explain the mechanism for the ammoxidation of propene which leads to the formation of…

A:

Q: How do you account for the fact that N-phenylacetamide (acetanilide) is less reactive toward…

A: Given statement, N-phenylacetamide is less reactive toward electrophilic aromatic substitution…

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

A: The structure of Y is as follows, In given reaction, the base abstracts the acidic proton from…

Q: (a) Explain why phentermine [PhCH2C(CH3)2NH2] can’t be made by a reductive amination reaction.(b)…

A: (a)The structure of phentermine is given below.

Q: What is the intermédiate state of an acid-base catalysis during conversion of DHAP to GAP called,…

A:

Q: Nabumetone is a pain reliever and anti-inflammatory agent sold under the brand name of Relafen. a.…

A: a) Please find below a synthesis of nabumetone from ethyl acetoacetate.

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.