Calcium enters into Free Radicals cause Sequence: Excitatory Amino Acid Damage and Death Glutamate binds to AMPA molecule neuron more damage AMPA channel Sodium enters into NMDA channel neuron opens opens Calcium activates nitric oxide synthetase Glutamate builds up within synapse ATP is not produced effectively in injured neuron Sodium-mediated Reactive oxygen species are formed Neuron death membrane depolarization Occurs Glutamate re-uptake is inhibited Direct ischemic injury Depolarization activates NMDA occurs to neuron

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