Carbon monoxide poisoning is a serious concern, even at low-levels of carbon monoxide in the air. Carbon monoxide preferentially replaces oxygen in oxygenated hemoglobin (Hb) according to the reaction: (bp)*0 + (bv)034H = (bn)0ɔ + (bp)*0qH Use the following reactions and associated equilibrium constants (at body temperature) to find the equilibrium constant for the reaction shown above. Hb(aq) + 02(aq) = HbO;(aq) K. = 1.8 Hb(aq) + CO(aq) = HBCO(aq) K = 306 Suppose that an air mixture becomes polluted with carbon monoxide at a level of 0.20%. Assuming the air contains 20.0% oxygen and that the oxygen and carbon monoxide ratios that dissolve in the blood are identical to the ratios in the air, what is the ratio of HBCO to HbO; in the bloodstream? Based on your calculations, just how toxic is carbon monoxide?

Chemistry for Engineering Students
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Author:Lawrence S. Brown, Tom Holme
Publisher:Lawrence S. Brown, Tom Holme
Chapter12: Chemical Equilibrium
Section: Chapter Questions
Problem 12.40PAE: Because carbonic acid undergoes a second ionization, the student in Exercise 12.39 is concerned that...
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Carbon monoxide poisoning is a serious concern, even at low-levels of carbon monoxide in the
air. Carbon monoxide preferentially replaces oxygen in oxygenated hemoglobin (Hb) according
to the reaction:
Hb0,(aq) + CO(aq) = HBCO(aq) + 02(aq)
Use the following reactions and associated equilibrium constants (at body temperature) to find
the equilibrium constant for the reaction shown above.
нь(ад) + 0,(аg) ӕ ньо,(аg) К. 3 1.8
нЬ ад) + со(аq) ӕ ньсо(ад)
Ke = 306
Suppose that an air mixture becomes polluted with carbon monoxide at a level of 0.20%.
Assuming the air contains 20.0% oxygen and that the oxygen and carbon monoxide ratios that
dissolve in the blood are identical to the ratios in the air, what is the ratio of HbCO to HbOz in
the bloodstream? Based on your calculations, just how toxic is carbon monoxide?
Transcribed Image Text:Carbon monoxide poisoning is a serious concern, even at low-levels of carbon monoxide in the air. Carbon monoxide preferentially replaces oxygen in oxygenated hemoglobin (Hb) according to the reaction: Hb0,(aq) + CO(aq) = HBCO(aq) + 02(aq) Use the following reactions and associated equilibrium constants (at body temperature) to find the equilibrium constant for the reaction shown above. нь(ад) + 0,(аg) ӕ ньо,(аg) К. 3 1.8 нЬ ад) + со(аq) ӕ ньсо(ад) Ke = 306 Suppose that an air mixture becomes polluted with carbon monoxide at a level of 0.20%. Assuming the air contains 20.0% oxygen and that the oxygen and carbon monoxide ratios that dissolve in the blood are identical to the ratios in the air, what is the ratio of HbCO to HbOz in the bloodstream? Based on your calculations, just how toxic is carbon monoxide?
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