CH3 OH DMB OH 2e HO HO A -DMB - DMB CH2 Adenine АТР Co+ Pi + PP, DMB
The following diagram shows the biosynthesis of B12 coenzymes, starting with the vitamin. DMB is dimethylbenzimidazole.
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme C would result in excessive
urinary excretion of what compound?
(c) Some forms of the condition described in (b) can be successfully treated
by injection of rather massive doses of vitamin B12. What kind of
genetic alteration in the enzyme would be consistent with this result?
(d) Genetic deficiency in animals of enzyme B will result in excessive urinary
excretion of what amino acid?
Introduction:
DAM is the derivative of natural benznidazole. The structure of the DAM is:
Explanation:
The non-protein substance that binds to the enzyme to catalyze the chemical reaction is known as a coenzyme. It is also known as cofactors.
a)
5-Methyltetrahydrofolate is required by enzyme B.
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