Clearly and neatly, draw a mechanism for the proposed synthesis of the anesthetic procaine (Novocain) in two (2) steps using p-nitrobenzoic acid anhydride (1) and N,N-diethylethanol amine (2). Be sure to note approximate equivalents for each reagent, solvents, all isolable intermediates, and conditions for isolation/ purification of the final product.

Clearly and neatly, draw a mechanism for the proposed synthesis of the anesthetic procaine (Novocain) in two (2) steps using p-nitrobenzoic acid anhydride (1) and N,N-diethylethanol amine (2). Be sure to note approximate equivalents for each reagent, solvents, all isolable intermediates, and conditions for isolation/ purification of the final product.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter31: Immunochemistry

Section: Chapter Questions

Problem 31.70P

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