co-spot of carbonyl & alcohol compounds A 0 Your alcohol product, B (obtained from the NaBH4 reduction reaction of the carbonyl starting material, A) is purified by column chromatography. You obtain the following TLC of the column chromatography fractions. 000 1 TLC Chromatography Fractions 2 0- NaBH4 MeOH H₂O 0 3₂ 0 0 0 1 4 5 B 6 0-1 q OH 7 1.8 cm 2.8 cm 3.2 cm

Principles of Instrumental Analysis
7th Edition
ISBN:9781305577213
Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Chapter28: High-performance Liquid Chromatography
Section: Chapter Questions
Problem 28.19QAP
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What is the Rf of your alcohol product B? Which fractions would you combine to isolate pure alcohol product B?

 

 

 

co-spot of
carbonyl &
alcohol
compounds
A
0
Your alcohol product, B (obtained from the NaBH4 reduction reaction of the carbonyl
starting material, A) is purified by column chromatography. You obtain the following TLC
of the column chromatography fractions.
000
1
TLC Chromatography Fractions
2
0-
NaBH4
MeOH
H₂O
0
3
0 0 0
1
4
5
B
6
0-1
1
OH
7
1.8 cm
2.8 cm
3.2 cm
Transcribed Image Text:co-spot of carbonyl & alcohol compounds A 0 Your alcohol product, B (obtained from the NaBH4 reduction reaction of the carbonyl starting material, A) is purified by column chromatography. You obtain the following TLC of the column chromatography fractions. 000 1 TLC Chromatography Fractions 2 0- NaBH4 MeOH H₂O 0 3 0 0 0 1 4 5 B 6 0-1 1 OH 7 1.8 cm 2.8 cm 3.2 cm
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