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Compare and contrast the five classes of CD4T helper cells. Include in your response references to activation and effector function.
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- For question with blanks, choose the combination of answers that most accurately completes the statement.CD4 cells are ...................cells and CD8 cells are..................... cells. a. killer, suppressor c. cytotoxic, helper b. helper, cytotoxic d. B, TCompare and contrast CD4 and CD8 T cells. Include in your response references to structure, activation, and effector function.Why are CD8+/αβT-cells important? Explain the function of the mature activated CD8+/αβT-cell and list 3 cytotoxic effector molecules they secrete and 3 cytokines they secrete.
- Give typing answer with explanation and conclusion 1) What is the purpose of the CD4 and CD8 protein receptors?Outline the events that occur when an F+ cell encounters an F- cellWhat is one way that CD8+- cells are activated? A. by binding to a processed antigen on an MCH II protein located on a dendritic cell B. By interacting with a free floating antigen C. By binding to an antibody and secreting cytokines D. Th cells can produce cytokines to help activate CD8+- cells E. By phagocytosis of a bacteria
- CD4 cells are ___________ cells and CD8 cells are _________ cells.a. killer, suppressor b. helper, cytotoxic c. cytotoxic, helper d. B, TPlease answer fast Tolerance in the Thymus for CD4+ and CD8+ cells is carried out where? What is meant by positive and negative selection.Distinguish among the functions of the CDR1, CDR2, and CDR3segments of the T cell receptor.
- A metabolically stressed epithelial cell expresses the protein MICits surface and then interacts with a natural killer (NK) cell. What is the outcome of this interaction? A. MIC-A binds to NKG2D but is overruled by inhibitory receptors on the NK cell that bind to MHC-on the epithelial cells epithelial cell survives B. MIC-A binds to NKG2D, which activates the NK cell through sensing of "stress-induced The cell then kills the epithelial cell via apoptosis C. MIC-A binds to NKG2AInhibiting NK cell activation. The epithelial cell survivesExplain why each choice (a-d) is correct or incorrect. Which of the following examples below describes an autoimmune disease? a. Infection and death of T helper cells by a virus, resulting in a loss of adaptive immunity b. Release of bacterial endotoxins that block acetylcholine release result in muscle paralysis. c. Antibody binding to acetylcholine receptors of the motor end plate resulting in muscle weakness. d. Uncontrolled cell division resulting in cell surface abnormalities recognized by NK cells.Give typing answer with explanation and conclusion ADCC is an important mechanism for eliminating parasites and pathogen-infected cells. Go back and review the toxic materials present in eosinophils and NK cells (see Course Notes 2.1 and 2.2). List 5 of these toxins and state their effects on the target cells that have been tagged with antibodies. What kinds of antibodies are involved in triggering ADCC in each case (by eosinophils and by NK cells)?