CORRECT OR INCORRECT    Alkylating agents react with DNA and form covalent bonds.   Ciprofloxacin is a member of a group of compounds called fluoroquinolones which act by stabilizing a complex between the topoisomerase enzyme and DNA.   Chain cutting agents usually bind to DNA and generate radical species which result in the cutting of the DNA chain.   Intercalating agents are agents that can bind to DNA and insert planar regions of their skeleton between the base pairs of DNA.

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter23: Amines
Section: Chapter Questions
Problem 23.67P
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CORRECT OR INCORRECT 
 
Alkylating agents react with DNA and form covalent bonds.
 
Ciprofloxacin is a member of a group of compounds called fluoroquinolones which act by stabilizing a complex between the topoisomerase enzyme and DNA.
 
Chain cutting agents usually bind to DNA and generate radical species which result in the cutting of the DNA chain.
 
Intercalating agents are agents that can bind to DNA and insert planar regions of their skeleton between the base pairs of DNA.
 
Agents which inhibit the polymerization or depolymerization of microtubules are important anticancer agents.
 
Paclitaxel and its derivatives bind to tubulin and accelerate depolymerization by stabilizing the resulting microtubules.
 
Drugs that target viral structural proteins can prevent viruses from entering host cells by inhibiting the uncoating process.
 
Etoposide and Teniposide are non-intercalating drugs that act as Topoisomerase 1 poisons.
 
Camptothecin is a non-intercalating drug that acts as Topoisomerase I poison.
 
Nitrogen mustards react with guanine groups on DNA to produce cross-linking.
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