Daclatasvir is formulated at the dihydrochloride salt. Which functional group in Daclatasvir will be protonated? (structure shown below) OA Carbond
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- How can chirality and stereoisomers influence the pharmacology, bioactivity, toxicology, pharmacokinetics, and metabolism of ibuprofen? Please provide a detailed summary of what might happen if, for instance, the R enantiomer isn't able to be inverted to the bioactive S enantiomer.Given ß- Cyclodextrin, Briefly explain its expected reaction (based on their structural formula) to the different qualitative tests for carbohydrates which are: (a)Barfoed’s test (b)Seliwanoff’s test (c) Iodine’s testTriacyl glycerols can be hydrolyzed under basic conditions to give ________ (a 3 carbon compound) and __________.
- Draw the structure of the PTH derivative product you would obtain by Edman degradation of the following peptides: (a) I-L-P-F (b) D-T-S-G-AAs a substituent, the hydrocarbon “tail” of the Ibuprofen molecule (see circle above) can be best described as n-butyl.  sec-butyl. isobutyl. tert-butylDraw the structures of the following compounds. (Includes both new and old names.) 3-cyclopentylhexan-3-ol
- Which of the following define the stereochemistry of alanine (as per the structure shown)? Note: Functional groups arranged horizontally are facing towards the front, and the functional groups arranged vertically are facing towards the back. a) d- b) S- c) R- d) I-Given Tagatose, Briefly explain its expected reaction (based on their structural formula) to the different qualitative tests for carbohydrates which are: (a)Barfoed’s test (b)Seliwanoff’s test (c) Iodine’s testMethionine is an essential amino acid that can be metabolized to homocysteine. Using the figure below, describe the R-group on homocysteine and how it differs from methionine. Include the functionality of the thiol as part of this discussion.
- Why Ranitidine is better than Cemitidine? Please explain at your own words.Carvone exists as a pair of enantiomers. (R)-(-)-carvone smells like spearment, whereas (S)-(+)-carvone smells like caraway. Why do these enantiomers have different smells (i.e., different biological activity) ?A decapeptide has the following acid composition; Al2,Arg,Cys,Glu,Leu,Phe,Val Partial hydrolysis yield the following tripeptides; Cys-Glu-Leu+Gly-Arg-Cys+Leu-Ala-Ala+Lys-Val-Phe-Gly Reaction of the decapeptide with 2,4-dinitrofluorobenzene yields 2,4-dinitrophenylysine. From the experimental data, deduce the primary structure of the decapeptide. Suggest a scheme you will follow to synthesize the dipeptide Ala-Gly.