Daichi Yamada, 65 years old, immigrated to California to live with his son after the Fukushima tsunami and nuclear power plant disaster destroyed his community in 2011. Recently he began complaining of fatigue, left-side pain, abdominal fullness, and night sweats. His son scheduled a check-up for him, and a routine blood screening test showed elevated basophils and eosinophils. Bone marrow tests showed the Philadelphia chromosome by fluorescence in situ hybridization (FISH), confirming rearrangement between chromosomes 9 and 22, which occurs in 95% of cases of chronic myelogenous leukemia (CML). He also had an enlarged spleen and liver. A diagnosis of CML was made and treatment with the tyrosine kinase inhibitor imatinib mesylate (Gleevec) began. Over the next 4–8 weeks Daichi’s bone marrow showed regrowth of normal stem-cell populations, and stable white blood cell proportions were restored. Which of the following genes are associated with the chromosomal translocation in CML? a. p53 and Rb b. MIC-A and NKG2D c. MAGEA1 and MAGEA3 d. PD-L1 and PD-L2 e. BCR and ABL.
Daichi Yamada, 65 years old, immigrated to California to live with his son after the Fukushima tsunami and nuclear power plant disaster destroyed his community in 2011. Recently he began complaining of fatigue, left-side pain, abdominal fullness, and night sweats. His son scheduled a check-up for him, and a routine blood screening test showed elevated basophils and eosinophils. Bone marrow tests showed the Philadelphia chromosome by fluorescence in situ hybridization (FISH), confirming rearrangement between chromosomes 9 and 22, which occurs in 95% of cases of chronic myelogenous leukemia (CML). He also had an enlarged spleen and liver. A diagnosis of CML was made and treatment with the tyrosine kinase inhibitor imatinib mesylate (Gleevec) began. Over the next 4–8 weeks Daichi’s bone marrow showed regrowth of normal stem-cell populations, and stable white blood cell proportions were restored. Which of the following genes are associated with the chromosomal translocation in CML? a. p53 and Rb b. MIC-A and NKG2D c. MAGEA1 and MAGEA3 d. PD-L1 and PD-L2 e. BCR and ABL.
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter13: Modern Understandings Of Inheritance
Section: Chapter Questions
Problem 2VCQ: Figure 13.4 Which of the following statements is true? Recombination of the body color and red/...
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| Daichi Yamada, 65 years old, immigrated to California to live with his son after the Fukushima tsunami and nuclear power plant disaster destroyed his community in 2011. Recently he began complaining of fatigue, left-side pain, abdominal fullness, and night sweats. His son scheduled a check-up for him, and a routine blood screening test showed elevated basophils and eosinophils. Bone marrow tests showed the Philadelphia chromosome by fluorescence in situ hybridization (FISH), confirming rearrangement between chromosomes 9 and 22, which occurs in 95% of cases of chronic myelogenous leukemia (CML). He also had an enlarged spleen and liver. A diagnosis of CML was made and treatment with the tyrosine kinase inhibitor imatinib mesylate (Gleevec) began. Over the next 4–8 weeks Daichi’s bone marrow showed regrowth of normal stem-cell populations, and stable white blood cell proportions were restored. Which of the following genes are associated with the chromosomal translocation in CML? |
| a. p53 and Rb |
| b. MIC-A and NKG2D |
| c. MAGEA1 and MAGEA3 |
| d. PD-L1 and PD-L2 |
| e. BCR and ABL. |
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