Define the term Inflammation and Immune Responses of the kidney?
Define the term Inflammation and Immune Responses of the kidney?
Any individual's ability to fight with any non-self body cell or protein that can harm its body is known as immunity. The response generated by the individual against that non-self component is called the immune response.
The body's immune response against any pathogen or non-self component that involves blood vessels, immune cells, and chemical mediators is known as inflammation. Heat, pain, swelling, redness or edema, and loss of function describe the classical signs of inflammation in an area.
The excretory system's organs called the kidneys to secrete hormones and host immune cells like macrophages, dendritic cells that function in generating an immune response on encountering a pathogen. The macrophages present in kidneys function to phagocytize any pathogen that affects the renal system for damage. The renal dendritic cells present antigens to the T cells on encountering a pathogen to generate antibodies. Vitamin D, which the kidneys synthesize, functions to regulate the calcium homeostasis in blood and phagocytosis. Erythropoietin, a hormone produced by the kidneys, increase the rate of red blood cell production for the blood, allowing the inflamed area to be redder. The immune system, however, in many cases, is responsible for kidney damage. The immune response of the macrophages of the kidney increases to a high-level, damage the renal cells. The body can sometimes make antibodies against the renal cell and cause inflammation in the glomerulus, nephron, and other renal disorders.
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